ArticleNeuron2018
Differential Control of Axonal and Somatic Resting Potential by Voltage-Dependent Conductances in Cortical Layer 5 Pyramidal Neurons.
Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 88 citations in OpenAlex.
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- Axon Initial Segment GABA Inhibits Action Potential Generation throughout Periadolescent Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Activity-dependent ectopic action potentials in regular-spiking neurons of the neocortex.Frontiers in cellular neuroscience · 2023Article
- Site and Mechanism of ML252 Inhibition of Kv7 Voltage-Gated Potassium Channels.Function (Oxford, England) · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Voltage-dependent conductances not only drive action potentials but also help regulate neuronal resting potential. We found differential regulation of resting potential in the proximal axon of layer 5 pyramidal neurons compared to the soma. Axonal resting potential was more negative than the soma, reflecting differential control by multiple voltage-dependent channels, including sodium channels, Cav3 channels, Kv7 channels, and HCN channels. Kv7 current is highly localized to the axon and HCN current to the soma and dendrite. Because of impedance asymmetry between the soma and axon, axonal Kv7 current has little effect on somatic resting potential, while somatodendritic HCN current strongly influences the proximal axon. In fact, depolarizing somatodendritic HCN current is critical for resting activation of all the other voltage-dependent conductances, including Kv7 in the axon. These experiments reveal complex interactions among voltage-dependent conductances to control region-specific resting potential, with somatodendritic HCN channels playing a critical enabling role.
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Registered trials
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