Evidence map›Paper›PMID 29526435›Full record

ArticleStructure (London, England : 1993)2018

Structural and Functional Insights into Bacillus subtilis Sigma Factor Inhibitor, CsfB.

Santiago Martínez-Lumbreras, Caterina Alfano, Nicola J Evans, Katherine M Collins, Kelly A Flanagan, R Andrew Atkinson, Ewelina M Krysztofinska, Anupama Vydyanath, Jacquelin Jackter, Sarah Fixon-Owoo and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Structure (London, England : 1993), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Structural Analysis ofMicroorganisms · 2023
    Article
  2. Article
  3. Sporulation in solventogenic and acetogenic clostridia.Applied microbiology and biotechnology · 2021
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. The roles of cytosolic quality control proteins, SGTA and the BAG6 complex, in disease.Advances in protein chemistry and structural biology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 3 countries.

Santiago Martínez-LumbrerasDepartment of Chemistry, King's College London, Britannia House, 7 Trinity Street, London SE1 1DB, UK.
Caterina AlfanoDepartment of Chemistry, King's College London, Britannia House, 7 Trinity Street, London SE1 1DB, UK; Structural Biology and Biophysics Unit, Fondazione Ri.MED, Via Bandiera, 11, 90133 Palermo, Italy.
Nicola J EvansDepartment of Chemistry, King's College London, Britannia House, 7 Trinity Street, London SE1 1DB, UK.
Katherine M CollinsDepartment of Chemistry, King's College London, Britannia House, 7 Trinity Street, London SE1 1DB, UK.
Kelly A FlanaganDepartment of Biological Sciences, Mount Holyoke College, 50 College Street, South Hadley, MA 01075, USA.
R Andrew AtkinsonCentre for Biomolecular Spectroscopy and Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, UK.
Ewelina M KrysztofinskaDepartment of Chemistry, King's College London, Britannia House, 7 Trinity Street, London SE1 1DB, UK.
Anupama VydyanathDepartment of Chemistry, King's College London, Britannia House, 7 Trinity Street, London SE1 1DB, UK.
Jacquelin JackterDepartment of Biological Sciences, Mount Holyoke College, 50 College Street, South Hadley, MA 01075, USA.
Sarah Fixon-OwooDepartment of Biological Sciences, Mount Holyoke College, 50 College Street, South Hadley, MA 01075, USA.
Amy H CampDepartment of Biological Sciences, Mount Holyoke College, 50 College Street, South Hadley, MA 01075, USA.
Rivka L IsaacsonDepartment of Chemistry, King's College London, Britannia House, 7 Trinity Street, London SE1 1DB, UK. Electronic address: rivka.isaacson@kcl.ac.uk.
King's College London · GBMount Holyoke College · US

Funding

A Feeding Tube Model for Bacterial Cell-Cell CommunicationDP2GM105439 · NIGMS · MOUNT HOLYOKE COLLEGE · PI CAMP, AMY HITCHCOCK · 2012 to 2012
$2.1M
A Switch in Gene Expression During Bacterial DevelopmentR15GM101559 · NIGMS · MOUNT HOLYOKE COLLEGE · PI CAMP, AMY HITCHCOCK · 2012 to 2012
$276k
British Heart Foundation IG/16/2/32273Medical Research Council G0900936Medical Research Council MC_U117533887NIGMS NIH HHS DP2 GM105439NIGMS NIH HHS R15 GM101559Wellcome Trust FC001029
6 · The paper itself

Abstract

Global changes in bacterial gene expression can be orchestrated by the coordinated activation/deactivation of alternative sigma (σ) factor subunits of RNA polymerase. Sigma factors themselves are regulated in myriad ways, including via anti-sigma factors. Here, we have determined the solution structure of anti-sigma factor CsfB, responsible for inhibition of two alternative sigma factors, σ

Indexed as

Gene Expression Regulation, BacterialAmino Acid SequenceBacillus subtilisBinding SitesCations, DivalentCloning, MolecularCrystallography, X-RayEscherichia coliGenetic VectorsModels, MolecularMutationProtein BindingProtein Conformation, alpha-HelicalProtein Conformation, beta-StrandProtein Interaction Domains and MotifsProtein IsoformsCations, DivalentProtein IsoformsRecombinant ProteinsRepressor ProteinsSigma FactorZincanti-sigma factorBacillus subtilisCsfBNMRsigma factorsporulationtreble clef

Identifiers

PMID29526435
PMCPMC5890618
OpenAlexW2790315963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.