Evidence map›Paper›PMID 29526406›Full record

ArticleJournal of neuroimmunology2018

Morphine-potentiated cognitive deficits correlate to suppressed hippocampal iNOS RNA expression and an absent type 1 interferon response in LP-BM5 murine AIDS.

Virginia D McLane, Saurabh Kumar, Reno Leeming, Sanjay Rau, Colin L Willis, Ling Cao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimmunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Effects of Morphine on Gp120-induced Neuroinflammation Under Immunocompetent Vs. Immunodeficient Conditions.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2023
    Article
  2. Effects of HIV gp120 on Neuroinflammation in Immunodeficient vs. Immunocompetent States.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021
    Article
  3. Opioid and neuroHIV Comorbidity - Current and Future Perspectives.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Virginia D McLaneUniversity of Maine, Graduate School of Biomedical Science and Engineering, Orono, ME 04669, USA; University of New England, College of Osteopathic Medicine, Biddeford, ME 04005, USA. Electronic address: virginia.mclane@vcuhealth.org.
Saurabh KumarUniversity of New England, College of Osteopathic Medicine, Biddeford, ME 04005, USA; North Andover High School, North Andover, MA 01845, USA.
Reno LeemingUniversity of New England, College of Osteopathic Medicine, Biddeford, ME 04005, USA; University of New England, College of Arts and Sciences, Biological Science Department, Biddeford, ME 04005, USA.
Sanjay RauUniversity of New England, College of Osteopathic Medicine, Biddeford, ME 04005, USA.
Colin L WillisUniversity of New England, College of Osteopathic Medicine, Biddeford, ME 04005, USA.
Ling CaoUniversity of New England, College of Osteopathic Medicine, Biddeford, ME 04005, USA. Electronic address: lcao@une.edu.
New England College · US

Funding

Tissue resident macrophages in sensory ganglia: function and impact on nociceptionP20GM103643 · NIGMS · UNIVERSITY OF NEW ENGLAND · PI MENG, IAN D · 2012 to 2021
$20.9M
Murine AIDS (LP-BM5) viral infection induced peripheral neuropathy - Role of CNSR21NS066130 · NINDS · UNIVERSITY OF NEW ENGLAND · PI CAO, LING · 2009 to 2010
$331k
NIGMS NIH HHS P20 GM103643NINDS NIH HHS R21 NS066130
6 · The paper itself

Abstract

Opioid use accelerates neurocognitive impairment in HIV/AIDS patients. We assessed the effect of chronic morphine treatment and LP-BM5/murine AIDS (MAIDS) infection on cognition, cytokine production, and type 1 interferon (IFN) expression in the murine CNS. Morphine treatment decreased expression of pro-inflammatory factors (CCL5, iNOS) and reduced cognitive performance in LP-BM5-infected mice, correlating to increased hippocampal viral load and a blunted type 1 IFN response. In the striatum, morphine reduced viral load while increasing IFN-α RNA expression. Our results suggest that differentially regulated type 1 IFN responses may contribute to distinct regional outcomes in the hippocampus and striatum in LP-BM5/MAIDS.

Indexed as

AIDS Dementia ComplexAnalgesics, OpioidAnimalsCognitive DysfunctionHippocampusInterferon Type IMaleMiceMice, Inbred C57BLMorphineMurine Acquired Immunodeficiency SyndromeNitric Oxide Synthase Type IIViral LoadAnalgesics, OpioidInterferon Type IMorphineNitric Oxide Synthase Type IINos2 protein, mouse

Identifiers

PMID29526406
PMCPMC5915896
OpenAlexW2792813224

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.