Evidence map›Paper›PMID 29526239›Full record

ArticleJournal of integrative medicine2018

Arnica montana experimental studies: confounders and biases?

Paolo Bellavite, Marta Marzotto, Clara Bonafini

Abstract readComment
PubMed Publisher
In one paragraph

Article in Journal of integrative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Paolo BellaviteDepartment of Medicine, University of Verona, Strada Le Grazie 8, Verona 37134, Italy.
Marta MarzottoDepartment of Medicine, University of Verona, Strada Le Grazie 8, Verona 37134, Italy. Electronic address: marta.marzotto@univr.it.
Clara BonafiniDepartment of Medicine, University of Verona, Strada Le Grazie 8, Verona 37134, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arnica montana is a popular traditional remedy widely used in complementary and alternative medicine, in part for its wound-healing properties. The authors recently showed that this plant extract and several of its homeopathic dilutions are able to modify the expression of a series of genes involved in inflammation and connective tissue regeneration. Their studies opened a debate, including criticisms to the "errors" in the methods used and the "confounders and biases". Here the authors show that the criticisms raised on methodology and statistics are not consistent and cannot be considered pertinent. The present comment also updates and reviews information concerning the action of A. montana dilutions in human macrophage cells while summarizing the major experimental advances reported on this interesting medicinal plant.

Indexed as

ArnicaPlant ExtractsBiasHumansPlants, MedicinalWound HealingPlant ExtractsArnica montanaEthanolGene expressionStatistics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.