Evidence map›Paper›PMID 29526184›Full record

ArticleDeutsches Arzteblatt international2018

Chronic Heart Failure.

Frank Edelmann, Christoph Knosalla, Klaus Mörike, Christiane Muth, Peggy Prien, Stefan Störk

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Deutsches Arzteblatt international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

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  14. βFrontiers in cardiovascular medicine · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Frank EdelmannMedical Department, Division of Cardiology and Angiology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum; Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, German Centre for Cardiovascular Research; Universitätsklinikum Tübingen, Department of Experimental and Clinical Pharmacology and Toxicology; Institute of General Practice, J.W. Goethe University, Frankfurt/Main; German Agency for Quality in Medicine (ÄZQ), Berlin; Comprehensive Heart Failure Center & Deptartment of Internal Medicine I, University and University Hospital Würzburg.
Christoph Knosalla
Klaus Mörike
Christiane Muth
Peggy Prien
Stefan Störk
German Agency for Quality in Medicine · DECharité - Universitätsmedizin Berlin · DEUniversitätsklinikum Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic heart failure (CHF) is the most common reason for hospital admissions in Germany. For the National Disease Management Guideline (NDMG) on CHF, a multidisciplinary expert panel revised the chapters on drug therapy, invasive therapy, and care coordination, following the methods of evidence-based medicine.

methodsRecommendations are based on international guideline adaptations or systematic literature search. They were developed by a multidisciplinary expert panel, approved in a formal consensus procedure, and tested in open consultation, as specified by the requirements for S3 guidelines.

resultsThe pharmacological treatment is based on ACE inhibitors, beta-blockers and mineralocorticoid receptor antagonists as well as diuretics to treat fluid retention, if present. Sacubitril/Valsartan and ivabradine showed positive effects on mortality in large but methodologically limited RCT. They are recommended if established combination therapy is not sufficient for symptom control, or if drugs are not tolerated/contraindicated. The indications for pacemakers or defibrillators have been confined to patient subgroups in which clinical trials have shown a clear benefit. Moreover, the goals of treatment and the patient's expectations should be aligned with each other. Structured care programs, specialized nurses, remote, or telephone monitoring showed moderate effects on patient related outcomes in RCT.

conclusionAll patients with heart failure are suggested to be enrolled in a structured program (e.g., a disease management program) including coordinated multidisciplinary care and continuous educational interventions. In patients with a poor prognosis, more intensive care is recommended, e.g. specialized nurses, or telephone support.

Indexed as

Adrenergic beta-AntagonistsAminobutyratesAngiotensin-Converting Enzyme InhibitorsBiphenyl CompoundsCardiac Resynchronization TherapyDiureticsDrug CombinationsGermanyGuidelines as TopicHeart FailureHumansIvabradineMineralocorticoid Receptor AntagonistsTetrazolesValsartanAdrenergic beta-AntagonistsAminobutyratesAngiotensin-Converting Enzyme InhibitorsBiphenyl CompoundsDiureticsDrug CombinationsIvabradineMineralocorticoid Receptor Antagonistssacubitril and valsartan sodium hydrate drug combinationTetrazolesValsartan

Identifiers

PMID29526184
PMCPMC5852309
OpenAlexW2794347428

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.