Evidence map›Paper›PMID 29526043›Full record

ReviewPain practice : the official journal of World Institute of Pain2018

Spinal Cord Stimulation: Clinical Efficacy and Potential Mechanisms.

Andrei D Sdrulla, Yun Guan, Srinivasa N Raja

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pain practice : the official journal of World Institute of Pain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05926843 (Evaluation of Spinal Cord Stimulation Assisted by Motor Rehabilitation Training for Restoring Motor Function After Spinal Cord Injury), which is not on this map. Cited by 176 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
176citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05926843 nacompletednot on this mapstarted 2023, after this paper: background citation

Evaluation of Spinal Cord Stimulation Assisted by Motor Rehabilitation Training for Restoring Motor Function After Spinal Cord Injury: an Interventional, Prospective, Monocentric Study

TypeinterventionalSponsorIRCCS San RaffaeleRan2023 to 2026Enrolled10ConditionsSpinal Cord InjuriesArmsSpinal cord stimulation surgery (device) and motor rehabilitation
3 · Its place in the literature

Who cites it

176 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  9. Implanted spinal neuromodulation interventions for chronic pain in adults.The Cochrane database of systematic reviews · 2021
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116 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Andrei D SdrullaDepartment of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon, U.S.A.
Yun GuanDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, U.S.A.
Srinivasa N RajaDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, U.S.A.

Funding

Mrgs as New Target for the Treatment of Neuropathic PainR01NS070814 · NINDS · JOHNS HOPKINS UNIVERSITY · PI GUAN, YUN · 2011 to 2020
$3.2M
CRCNS: Towards Pain Control: Synergizing Computational and Biological ApproachesR01AT009401 · NCCIH · JOHNS HOPKINS UNIVERSITY · PI SARMA, SRIDEVI V. · 2016 to 2019
$1.6M
Investigating the Neural Circuits of Spinal Cord StimulationK08NS099503 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI SDRULLA, ANDREI D · 2018 to 2022
$991k
Developing Novel Direct Current Stimulation Technology for Safe Precision Pain TreatmentR21NS099879 · NINDS · JOHNS HOPKINS UNIVERSITY · PI GUAN, YUN · 2016 to 2017
$449k
NCCIH NIH HHS R01 AT009401NINDS NIH HHS K08 NS099503NINDS NIH HHS R01 NS070814NINDS NIH HHS R21 NS099879
6 · The paper itself

Abstract

Spinal cord stimulation (SCS) is a minimally invasive therapy used for the treatment of chronic neuropathic pain. SCS is a safe and effective alternative to medications such as opioids, and multiple randomized controlled studies have demonstrated efficacy for difficult-to-treat neuropathic conditions such as failed back surgery syndrome. Conventional SCS is believed mediate pain relief via activation of dorsal column Aβ fibers, resulting in variable effects on sensory and pain thresholds, and measurable alterations in higher order cortical processing. Although potentiation of inhibition, as suggested by Wall and Melzack's gate control theory, continues to be the leading explanatory model, other segmental and supraspinal mechanisms have been described. Novel, non-standard, stimulation waveforms such as high-frequency and burst have been shown in some studies to be clinically superior to conventional SCS, however their mechanisms of action remain to be determined. Additional studies are needed, both mechanistic and clinical, to better understand optimal stimulation strategies for different neuropathic conditions, improve patient selection and optimize efficacy.

Indexed as

Treatment OutcomeChronic PainHumansNeuralgiaPain ManagementPain MeasurementSpinal CordSpinal Cord Stimulationcomplex regional pain syndromeslow back painpain syndromespostoperative painregional complexspinal cord stimulation

Identifiers

PMID29526043
PMCPMC6391880

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.