Evidence map›Paper›PMID 29525967›Full record

ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2019

Serum levels of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in predicting the severity of acute pancreatitis.

Baris Zulfikaroglu, Ferruh Kemal Isman, Gul Bora, Ozgur Akgul, Necdet Ozalp

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Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

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2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Baris ZulfikarogluDepartment of General Surgery, Ankara Numune Training and Research Hospital, 7. Cadde 70A /14, 06490-Bahcelievler, Ankara, Turkey. zbaris61@hotmail.com.
Ferruh Kemal IsmanDepartment of Clinical Chemistry, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey.
Gul BoraDepartment of General Surgery, Medical Park Ankara Hospital, Ankara, Turkey.
Ozgur AkgulDepartment of General Surgery, Ankara Numune Training and Research Hospital, 7. Cadde 70A /14, 06490-Bahcelievler, Ankara, Turkey.
Necdet OzalpDepartment of General Surgery, Medical Park Ankara Hospital, Ankara, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAcute pancreatitis (AP) is a severe disease associated with significant morbidity and mortality. The overall outcome has improved, but specific treatment(s) remains elusive. The challenge is the early identification and treatment of patients who will develop severe acute pancreatitis. Therefore, the aim of the present study is to investigate plasma levels of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the initial phase of predicted severe acute pancreatitis.

methodsBetween June 2014 and January 2016, 64 patients with acute pancreatitis and 36 healthy individuals were included to study. Four blood samples, for serum TWEAK measurement, were taken from each individual in each group. The first measurement was taken from the admission blood sample. The subsequent three samples were taken at 12, 24, and 48 h after the hospital admission.

resultsSerum TWEAK levels were significantly higher in patients with acute pancreatitis when compared with healthy controls. TWEAK plasma concentrations in severe pancreatitis patients were significantly higher than in mild pancreatitis patients.

conclusionSerum TWEAK levels increase progressively with the severity of acute pancreatitis and TWEAK might be a novel early marker of severity in acute pancreatitis.

Indexed as

AdultAgedCase-Control StudiesC-Reactive ProteinCytokine TWEAKEarly DiagnosisEarly Medical InterventionFemaleGallstonesHumansLipaseMaleMiddle AgedPancreatitisPancreatitis, AlcoholicPrognosisC-Reactive ProteinCytokine TWEAKLipaseTNFSF12 protein, humanAcute pancreatitisInflammationMarkerSeverityTumor necrosis factor-like weak inducer of apoptosis

Identifiers

PMID29525967

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