ReviewCurrent genetics2018
Frequent ploidy changes in growing yeast cultures.
Review in Current genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Evolutionary responses to increased opportunity for sexual selection in yeast.BMC ecology and evolution · 2026Article
- Evolutionary responses to increased opportunity for sexual selection in yeast.bioRxiv : the preprint server for biology · 2025Article
- Cln3 can work independently of Whi5 on the cell size for Start in yeast.bioRxiv : the preprint server for biology · 2025Article
- Theoretical Study of Sphingomyelinases fromPathogens (Basel, Switzerland) · 2025Article
- Comparative adaptability of 307Frontiers in microbiology · 2025Article
- Mutations in yeast are deleterious on average regardless of the degree of adaptation to the testing environment.Proceedings. Biological sciences · 2024Article
- Local endoreduplication of the host is a conserved process during Phytomyxea-host interaction.Frontiers in microbiology · 2024Article
- An increase in polyadenylation of histone isoforms, Hist1h2ah and Hist2h3c2, is governed by 3'-UTR in de-differentiated and undifferentiated hepatocyte.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Pheromone Response and Mating Behavior in Fission Yeast.Microbiology and molecular biology reviews : MMBR · 2022Review
- Recent insights into the evolution of mutation rates in yeast.Current opinion in genetics & development · 2022Review
- Neural networks enable efficient and accurate simulation-based inference of evolutionary parameters from adaptation dynamics.PLoS biology · 2022Article
- The genetic basis of differential autodiploidization in evolving yeast populations.G3 (Bethesda, Md.) · 2021Article
- Review
- The role of gene dosage in budding yeast centrosome scaling and spontaneous diploidization.PLoS genetics · 2020Article
- Genetic Engineering and Synthetic Genomics in Yeast to Understand Life and Boost Biotechnology.Bioengineering (Basel, Switzerland) · 2020Review
- MAT heterozygosity and the second sterility barrier in the reproductive isolation of Saccharomyces species.Current genetics · 2020Article
- Two mating-type genes MAT1-1-1 and MAT1-1-2 with significant functions in conidiation, stress response, sexual development, and pathogenicity of rice false smut fungus Villosiclava virens.Current genetics · 2020Article
- Evaluating the probability of CRISPR-based gene drive contaminating another species.Evolutionary applications · 2020Article
- Chance and necessity in the pleiotropic consequences of adaptation for budding yeast.Nature ecology & evolution · 2020Article
- Assessing Population Diversity ofFrontiers in microbiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ploidy is considered a very stable cellular characteristic. Although rare, changes in ploidy play important roles in the acquisition of long-term adaptations. Since these duplications allow the subsequent loss of individual chromosomes and accumulation of mutations, changes in ploidy can also cause genomic instability, and have been found to promote cancer. Despite the importance of the subject, measuring the rate of whole-genome duplications has proven extremely challenging. We have recently measured the rate of diploidization in yeast using long-term, in-lab experiments. We found that spontaneous diploidization occurs frequently, by two different mechanisms: endoreduplication and mating type switching. Despite its common occurrence, spontaneous diploidization is usually selected against, although it can be advantageous under some stressful conditions. Our results have implications for the understanding of evolutionary processes, as well as for the use of yeast cells in biotechnological applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.