Evidence map›Paper›PMID 29525790›Full record

ArticleAmerican journal of nephrology2018

Race/Ethnicity, Dietary Acid Load, and Risk of End-Stage Renal Disease among US Adults with Chronic Kidney Disease.

Deidra C Crews, Tanushree Banerjee, Donald E Wesson, Hal Morgenstern, Rajiv Saran, Nilka Ríos Burrows, Desmond E Williams, Neil R Powe, Centers for Disease Control and Prevention Chronic Kidney Disease Surveillance Team

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Dietary Protein Intake in CKD: Quantity and Quality.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. The therapeutic importance of acid-base balance.Biochemical pharmacology · 2021
    Review
  10. Review
  11. Article
  12. Article
  13. Kidney international reports · 2019
    Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Deidra C CrewsDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Tanushree BanerjeeDivision of General Internal Medicine, Department of Medicine, University of California, San Francisco, California, USA.
Donald E WessonDiabetes Health and Wellness Institute, Baylor Scott and White Health, Dallas, Texas, USA.
Hal MorgensternDepartments of Epidemiology and Environmental Health Sciences, School of Public Health, and Department of Urology, Medical School, University of Michigan, Ann Arbor, Michigan, USA.
Rajiv SaranKidney Epidemiology and Cost Center, University of Michigan, Ann Arbor, Michigan, USA.
Nilka Ríos BurrowsDivision of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Desmond E WilliamsCenter for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Neil R PoweDivision of General Internal Medicine, Department of Medicine, University of California, San Francisco, California, USA.
Centers for Disease Control and Prevention Chronic Kidney Disease Surveillance Team
University of Michigan–Ann Arbor · USBaylor Scott & White Health · USCenter for Global Health · USCenters for Disease Control and Prevention · USJohns Hopkins Medicine · USSan Francisco General Hospital · USUniversity of California, San Francisco · US

Funding

An Individually Tailored, Family-Centered Intervention for Childhood Obesity: Connecting Services in Pediatric Primary Healthcare, the Home, and the CommunityU18DP006255 · DP · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI BERKEL, CADY, SMITH, JUSTIN D · 2016 to 2017
$3.8M
ESTABLISHING A SURVEILLANCE SYSTEM FOR CHRONIC KIDNEY DISEASE IN THE U.S.U58DP003839 · DP · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POWE, NEIL R. · 2011 to 2014
$1.8M
Race, Socioeconomic Status, Diet and Chronic Kidney DiseaseK23DK097184 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI CREWS, DEIDRA CANDICE · 2013 to 2016
$684k
ACL HHS U18DP006255NCCDPHP CDC HHS U18 DP006255NCCDPHP CDC HHS U58 DP003839NIDDK NIH HHS K23 DK097184
6 · The paper itself

Abstract

backgroundDietary acid load (DAL) contributes to the risk of CKD and CKD progression. We sought to determine the relation of DAL to racial/ethnic differences in the risk of end-stage renal disease (ESRD) among persons with CKD.

methodsAmong 1,123 non-Hispanic black (NHB) and non-Hispanic white (NHW) National Health and Nutrition Examination Survey III participants with estimated glomerular filtration rate 15-59 mL/min/1.73 m2, DAL was estimated using the Remer and Manz net acid excretion (NAEes) formula and 24-h dietary recall. ESRD events were ascertained via linkage with Medicare. A competing risk model (accounting for death) was used to estimate the hazard ratio (HR) for treated ESRD, comparing NHBs with NHWs, adjusting for demographic, clinical and nutritional factors (body surface area, total caloric intake, serum bicarbonate, protein intake), and NAEes. Additionally, whether the relation of NAEes with ESRD risk varied by race/ethnicity was tested.

resultsAt baseline, NHBs had greater NAEes (50.9 vs. 44.2 mEq/day) than NHWs. It was found that 22% developed ESRD over a median of 7.5 years. The unadjusted HR comparing NHBs to NHWs was 3.35 (95% CI 2.51-4.48) and adjusted HR (for factors above) was 1.68 (95% CI 1.18-2.38). A stronger association of NAE with risk of ESRD was observed among NHBs (adjusted HR per mEq/day increase in NAE 1.21, 95% CI 1.12-1.31) than that among NHWs (HR 1.08, 95% CI 0.96-1.20), p interaction for race/ethnicity × NAEes = 0.004.

conclusionsAmong US adults with CKD, the association of DAL with progression to ESRD is stronger among NHBs than NHWs. DAL is worthy of further investigation for its contribution to kidney outcomes across race/ethnic groups.

Indexed as

AdultAgedDietDisease ProgressionFemaleHumansKidney Failure, ChronicMaleMiddle AgedNutrition SurveysUnited StatesAcid-baseEpidemiologyIncidence

Identifiers

PMID29525790
PMCPMC5906156
OpenAlexW2793807341

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.