Evidence map›Paper›PMID 29525782›Full record

ArticleJournal of the American Heart Association2018

Relations of Sex to Diagnosis and Outcomes in Acute Coronary Syndrome.

Nils Arne Sörensen, Johannes Tobias Neumann, Francisco Ojeda, Sarina Schäfer, Christina Magnussen, Till Keller, Karl J Lackner, Tanja Zeller, Mahir Karakas, Thomas Münzel and 3 more

2 registry-linked trialsOpen access · goldAbstract readComparative Study
In one paragraph

Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02355457 recruitingnot on this map

Biomarkers in Acute Cardiac Care

Typeobservational_patient_registrySponsorUniversitätsklinikum Hamburg-EppendorfRan2013 to 2027Enrolled5,000ConditionsAcute Coronary Syndrome, Myocardial Infarction, Chest Pain
NCT03227159 completednot on this map

Study for Evaluation of Newly Onset Chest Pain and Rapid Diagnosis of Myocardial Necrosis (stenoCARDIA)

TypeobservationalSponsorUniversitätsklinikum Hamburg-EppendorfRan2007 to 2008Enrolled1,818ConditionsAcute Myocardial Infarction
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Nils Arne SörensenDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Germany.
Johannes Tobias NeumannDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Germany.
Francisco OjedaDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Germany.
Sarina SchäferDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Germany.
Christina MagnussenDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Germany.
Till KellerDepartment of Cardiology, Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany.
Karl J LacknerGerman Center for Cardiovascular Research, Partner Site RheinMain, Hamburg, Germany.
Tanja ZellerDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Germany.
Mahir KarakasDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Germany.
Thomas MünzelGerman Center for Cardiovascular Research, Partner Site RheinMain, Hamburg, Germany.
Stefan BlankenbergDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Germany.
Dirk WestermannDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Germany.
Renate B SchnabelDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Germany r.schnabel@uke.de.
German Centre for Cardiovascular Research · DEUniversität Hamburg · DEUniversity Medical Center Hamburg-Eppendorf · DEJohannes Gutenberg University Mainz · DEKerckhoff Klinik · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe atypical presentation of women with acute coronary syndrome (ACS) has been related to delayed diagnosis and treatment, which may explain worse outcome compared with men. METHODS AND

resultsWe analyzed pooled data of 2520 patients of 2 prospective cohorts in terms of differences in presentation and management of women and men suggestive of ACS. Using logistic regression, we established 2 diagnostic models and tested their diagnostic performance in both sexes separately. Sex-specific differences in management of patients with ACS were ascertained and a 2-year follow-up was performed. Women were older than men (median 67 versus 61 years,

conclusionsIn a large cohort of patients with suspected ACS, sex differences in clinical presentation did not impair diagnostic accuracy. Two-year outcomes were comparable. Our findings suggest a benefit of chest pain units to minimize sex differences in ACS management and prognosis. CLINICAL

trial registrationURL: https://www.clinicaltrials.gov. Unique identifiers: NCT02355457 (BACC), NCT03227159 (stenoCardia).

Indexed as

Acute Coronary SyndromeAgedFemaleGermanyHealthcare DisparitiesHealth Status DisparitiesHumansIncidenceMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsRisk AssessmentRisk FactorsSex FactorsTime Factorsdiagnosisoutcomesex‐specifictroponin

Identifiers

PMID29525782
PMCPMC5907542
OpenAlexW2793631887

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.