Evidence map›Paper›PMID 29525778›Full record

ArticleJournal of the American Heart Association2018

Provider Specialty, Anticoagulation Prescription Patterns, and Stroke Risk in Atrial Fibrillation.

Wesley T O'Neal, Pratik B Sandesara, J'Neka S Claxton, Richard F MacLehose, Lin Y Chen, Lindsay G S Bengtson, Alanna M Chamberlain, Faye L Norby, Pamela L Lutsey, Alvaro Alonso

Open access · goldAbstract readComparative Study
In one paragraph

Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. A Systematic Review of Network Meta-Analyses and Real-World Evidence Comparing Apixaban and Rivaroxaban in Nonvalvular Atrial Fibrillation.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Pooled it
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  7. Insertable cardiac monitoring results in higher rates of atrial fibrillation diagnosis and oral anticoagulation prescription after ischaemic stroke.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
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  9. Direct Oral Anticoagulants and Warfarin for Atrial Fibrillation Treatment: Rural and Urban Trends in Medicare Beneficiaries.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Wesley T O'NealDivision of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA wesley.oneal@emory.edu.
Pratik B SandesaraDivision of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA.
J'Neka S ClaxtonDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
Richard F MacLehoseDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
Lin Y ChenCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN.
Lindsay G S BengtsonHealth Economics and Outcomes Research, Life Sciences, Optum, Eden Prairie, MN.
Alanna M ChamberlainDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN.
Faye L NorbyDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
Pamela L LutseyDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
Emory University · USUniversity of Minnesota · USChamberlain University · USOptum (United States) · USUniversity of Minnesota Medical Center · US

Funding

Comparative Effectiveness of Oral Anticoagulants in Atrial FibrillationR01HL122200 · NHLBI · UNIVERSITY OF MINNESOTA · PI ALONSO, ALVARO · 2015 to 2017
$1.2M
The Association between Acute Mental Stress and Electrocardiographic Left Atrial AbnormalitiesF32HL134290 · NHLBI · EMORY UNIVERSITY · PI O'NEAL, WESLEY T · 2016 to 2017
$122k
American Heart Association-American Stroke Association 16EIA26410001NHLBI NIH HHS F32 HL134290NHLBI NIH HHS R01 HL122200
6 · The paper itself

Abstract

backgroundDifferences in anticoagulation rates and direct oral anticoagulant use by provider specialty may identify an area of practice improvement to reduce future stroke events in patients with atrial fibrillation (AF). METHODS AND

resultsWe examined anticoagulant prescription fills in 388 045 (mean age, 68±15 years; 59% male) patients with incident AF from the MarketScan databases between 2009 and 2014. Provider specialty and filled anticoagulant prescriptions around the time of AF diagnosis (3 months before through 6 months after) were obtained from outpatient services and pharmacy claims. We estimated the association of provider specialty (cardiology versus primary care) with filling oral anticoagulant prescriptions, adjusting for patient characteristics. The risk of stroke and bleeding events also was explored. A total of 235 739 patients (61%) had a cardiology provider claim, whereas 152 306 (39%) were exclusively managed by primary care. Patients seen by cardiology providers were more likely to fill anticoagulant prescriptions than those seen by primary care (39% versus 27%; relative risk, 1.39; 95% confidence interval [CI], 1.37-1.40). Differences were observed for direct oral anticoagulants (relative risk, 1.74; 95% CI, 1.71-1.78) and warfarin (relative risk, 1.24; 95% CI, 1.22-1.26). A reduced risk of stroke events was observed among those seen by cardiology providers (hazard ratio, 0.90; 95% CI, 0.86-0.94) compared with primary care, without an increased bleeding risk (hazard ratio, 1.03; 95% CI, 0.98-1.07).

conclusionsPatients seen by an outpatient cardiology provider shortly after AF diagnosis were more likely to initiate oral anticoagulation and were at lower risk of future stroke events without a higher rate of bleeding. Early referral to cardiology specialists may increase initiation of anticoagulant therapies and improve outcomes in AF.

Indexed as

Administration, OralAgedAged, 80 and overAnticoagulantsAtrial FibrillationCardiologistsDatabases, FactualDrug PrescriptionsFemaleHemorrhageHumansIncidenceMaleMiddle AgedPhysicians, Primary CarePractice Patterns, Physicians'Anticoagulantsanticoagulationatrial fibrillationoutcomes

Identifiers

PMID29525778
PMCPMC5907557
OpenAlexW2789592440

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.