Evidence map›Paper›PMID 29525545›Full record

ArticleThe Knee2018

Time between anterior cruciate ligament injury and reconstruction and cartilage metabolism six-months following reconstruction.

Hope C Davis, Jeffery T Spang, Richard F Loeser, Staffan Larsson, Veronica Ulici, J Troy Blackburn, R Alexander Creighton, Ganesh M Kamath, Joanne M Jordan, Stephen W Marshall and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Knee, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Hope C DavisHuman Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. Electronic address: davishc@live.unc.edu.
Jeffery T SpangDepartment of Orthopaedics, School of Medicine, University of North Carolina at Chapel Hill, NC, United States.
Richard F LoeserThurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, United States.
Staffan LarssonLund University, Department of Clinical Sciences, Orthopaedics, Lund, Sweden.
Veronica UliciThurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, United States.
J Troy BlackburnHuman Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
R Alexander CreightonDepartment of Orthopaedics, School of Medicine, University of North Carolina at Chapel Hill, NC, United States.
Ganesh M KamathDepartment of Orthopaedics, School of Medicine, University of North Carolina at Chapel Hill, NC, United States.
Joanne M JordanThurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, United States.
Stephen W MarshallInjury Prevention Research Center, University of North Carolina at Chapel Hill, NC, United States.
Brian PietrosimoneHuman Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
University of North Carolina at Chapel Hill · USLund University · SE

Funding

Posttraumatic Osteoarthritis: Establishing a Comprehensive Evaluation StrategyR03AR066840 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PIETROSIMONE, BRIAN · 2015 to 2016
$152k
NIAMS NIH HHS R03 AR066840
6 · The paper itself

Abstract

backgroundTo determine the association between time from injury to ACL reconstruction (Time

methodsIndividuals with a unilateral ACL injury were enrolled at initial presentation in the orthopedic clinic; blood was collected six months following ACLR. Enzyme-linked immunosorbent assays were used to analyze the ratio of serum concentrations of type-II collagen breakdown (C2C) to synthesis (CPII), plasma matrix metalloproteinase-3 (MMP-3), interleukin-6 (IL-6), and serum aggrecan neoepitope (ARGS). We used separate linear regressions to assess associations between biochemical markers and Time

resultsTwenty-two participants (50% females, mean [SD], age 21.9 [4.5] years old; BMI 23.8 [2.6] kg/m

conclusionsGreater time between injury and ACL reconstruction was associated with greater serum C2C:CPII six months following ACLR in males but not females, and IL-6, MMP-3, and ARGS levels were not associated with Time

Indexed as

AggrecansAnterior Cruciate Ligament InjuriesCartilage, ArticularChondrogenesisCohort StudiesCollagen Type IIEnzyme-Linked Immunosorbent AssayFemaleFollow-Up StudiesHumansInterleukin-6Linear ModelsMaleMatrix Metalloproteinase 3Time-to-TreatmentYoung AdultAggrecansCollagen Type IIInterleukin-6Matrix Metalloproteinase 3ACLRBiomarkersC2CCPIIC-propeptide of type II procollagenType-II collagen cleavage product

Identifiers

PMID29525545
PMCPMC5886724
OpenAlexW2793336385

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.