Evidence map›Paper›PMID 29525282›Full record

ArticleVaccine2018

Characterization of the immune response elicited by the vaccinia virus L3 protein delivered as naked DNA.

Maite Ramírez, Saritza Santos, Osmarie Martínez, Ricardo Rodríguez, Eric Miranda, Willy D Ramos-Perez, Miguel Otero

Open access · hybridAbstract read
In one paragraph

Article in Vaccine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Maite RamírezDepartment of Microbiology, University of Puerto Rico, Medical Sciences Campus, San Juan, PR, USA. Electronic address: mayte.ramirez@upr.edu.
Saritza SantosDepartment of Microbiology, University of Puerto Rico, Medical Sciences Campus, San Juan, PR, USA. Electronic address: saritza.santos@upr.edu.
Osmarie MartínezDepartment of Microbiology, University of Puerto Rico, Medical Sciences Campus, San Juan, PR, USA. Electronic address: osmarie.martinez@upr.edu.
Ricardo RodríguezUniversity of Puerto Rico, Medical Sciences Campus, School of Medicine, San Juan, PR, USA. Electronic address: ricardo.rodriguez44@upr.edu.
Eric MirandaDepartment of Microbiology, University of Puerto Rico, Medical Sciences Campus, San Juan, PR, USA. Electronic address: eric.miranda@upr.edu.
Willy D Ramos-PerezDepartment of Microbiology, University of Puerto Rico, Medical Sciences Campus, San Juan, PR, USA. Electronic address: willy.ramos@upr.edu.
Miguel OteroDepartment of Microbiology, University of Puerto Rico, Medical Sciences Campus, San Juan, PR, USA. Electronic address: miguel.otero2@upr.edu.
University of Puerto Rico, Medical Sciences Campus · PR

Funding

Upstream Regulation and Downstream effectors of c-MYC in Ovarian CancerU54MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Emma Fernandez-Repollet · 2017 to 2026
$35.8M
SUPPLEMENT FOR RENOVATION OF ANIMAL FACILITIES AT INSTITUTE OF NEUROBIOLOGYG12RR003051 · NCRR · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI FERNANDEZ-REPOLLET, EMMA · 1986 to 2011
$28.1M
RISE Option III: MBRS RISE at the UPR Medical Sciences CampusR25GM061838 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CADILLA, CARMEN LYDIA · 2000 to 2021
$25.5M
TRANSLATIONAL PROTEOMICS CENTERG12MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI FERNANDEZ-REPOLLET, EMMA · 2012 to 2016
$11.0M
Vaccine Development against Infectious DiseasesSC3GM116698 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI OTERO, MIGUEL · 2016 to 2019
$450k
NCRR NIH HHS G12 RR003051NIGMS NIH HHS R25 GM061838NIGMS NIH HHS SC3 GM116698NIMHD NIH HHS G12 MD007600NIMHD NIH HHS U54 MD007600
6 · The paper itself

Abstract

Poxviruses are complex dsDNA viruses with over 200 genes, many of them with unknown role in the stimulation of immune responses. Among these, the vaccinia virus (VACV) L3L ORF encodes an essential protein for the transcription of the VACV early genes. To the best of our knowledge, the immune response elicited by L3 has not been characterized. In this regard, our data describes a DNA L3-coding plasmid (pL3L) that stimulates both, humoral- and cell-mediated immune responses in a mouse model. Cell-mediated immune responses were measured by IFN-γ and IL-4 ELISPOT assays. We performed CD8

Indexed as

Amino Acid SequenceAnimalsAntibodies, ViralAntigens, ViralCytokinesDNA, ViralFemaleImmunityImmunity, HumoralImmunodominant EpitopesImmunoglobulin GMicePeptidesT-Lymphocyte SubsetsVaccines, DNAVacciniaAntibodies, ViralAntigens, ViralCytokinesDNA, ViralImmunodominant EpitopesImmunoglobulin GPeptidesVaccines, DNAViral ProteinsBioterror agentsDNA-vaccineL3LNovel antigenSmallpoxVaccine

Identifiers

PMID29525282
PMCPMC6065253
OpenAlexW2789835847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.