ArticleCell systems2018
Modeling Cell-to-Cell Communication Networks Using Response-Time Distributions.
Article in Cell systems, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Decoding cellular population dynamics through mechanistic modelling and statistical data analysis.NPJ systems biology and applications · 2026Review
- Amplification cycles through innate lymphoid cells at the onset of lupus nephritis.Frontiers in immunology · 2026Article
- CellNEST reveals cell-cell relay networks using attention mechanisms on spatial transcriptomics.Nature methods · 2025Article
- Description of chemical systems by means of response functions.Journal of mathematical biology · 2025Article
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- Diffusion-limited cytokine signaling in T cell populations.iScience · 2024Article
- Bridging systems biology and tissue engineering: Unleashing the full potential of complex 3DBiophysics reviews · 2024Review
- Density physics-informed neural networks reveal sources of cell heterogeneity in signal transduction.Patterns (New York, N.Y.) · 2024Article
- Timed Pulses in DNA Strand Displacement Reactions.Journal of the American Chemical Society · 2023Article
- Distribution modeling quantifies collective TScience advances · 2023Article
- Review
- Spatially coordinated collective phosphorylation filters spatiotemporal noises for precise circadian timekeeping.iScience · 2023Article
- DEGBOE: Discrete time Evolution modeling of Gene mutation through Bayesian inference using qualitative Observation of mutation Events.Journal of biomedical informatics · 2022Article
- Dynamically modeling the effective range of IL-2 dosage in the treatment of systemic lupus erythematosus.iScience · 2022Article
- Article
- Protease-controlled secretion and display of intercellular signals.Nature communications · 2022Article
- Dissecting the dynamic transcriptional landscape of early T helper cell differentiation into Th1, Th2, and Th1/2 hybrid cells.Frontiers in immunology · 2022Article
- Cell-cell interactions and fluctuations in the direction of motility promote directed migration of osteoblasts in direct current electrotaxis.Frontiers in bioengineering and biotechnology · 2022Article
- A single-cell resolved cell-cell communication model explains lineage commitment in hematopoiesis.Development (Cambridge, England) · 2021Article
- Cell-Cell Communication Networks in Tissue: Toward Quantitatively Linking Structure with Function.Current opinion in systems biology · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Cell-to-cell communication networks have critical roles in coordinating diverse organismal processes, such as tissue development or immune cell response. However, compared with intracellular signal transduction networks, the function and engineering principles of cell-to-cell communication networks are far less understood. Major complications include: cells are themselves regulated by complex intracellular signaling networks; individual cells are heterogeneous; and output of any one cell can recursively become an additional input signal to other cells. Here, we make use of a framework that treats intracellular signal transduction networks as "black boxes" with characterized input-to-output response relationships. We study simple cell-to-cell communication circuit motifs and find conditions that generate bimodal responses in time, as well as mechanisms for independently controlling synchronization and delay of cell-population responses. We apply our modeling approach to explain otherwise puzzling data on cytokine secretion onset times in T cells. Our approach can be used to predict communication network structure using experimentally accessible input-to-output measurements and without detailed knowledge of intermediate steps.
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Registered trials
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