Evidence map›Paper›PMID 29525179›Full record

ArticleNeurobiology of aging2018

Genetic markers of dopaminergic transmission predict performance for older males but not females.

Kathleen E Hupfeld, David E Vaillancourt, Rachael D Seidler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Association between neuromelanin-sensitive MRI signal and psychomotor slowing in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
  10. Article
  11. Impact of dopamine-related genetic variants on physical activity in old age - a cohort study.The international journal of behavioral nutrition and physical activity · 2020
    Article
  12. Influence of Striatal Dopamine, Cerebral Small Vessel Disease, and Other Risk Factors on Age-Related Parkinsonian Motor Signs.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kathleen E HupfeldDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA. Electronic address: khupfeld@ufl.edu.
David E VaillancourtDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA; Center for Movement Disorders and Neurorestoration, Department of Neurology, University of Florida, Gainesville, FL, USA; Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Rachael D SeidlerDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA; School of Kinesiology, University of Michigan, Ann Arbor, MI, USA.

Funding

Scaling and Sequencing Motor Output in Humans: fMRI StudyR01NS052318 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI VAILLANCOURT, DAVID E · 2005 to 2020
$6.0M
Interdisciplinary Training in Movement Disorders and NeurorestorationT32NS082168 · NINDS · UNIVERSITY OF FLORIDA · PI Melissa Jo Armstrong, David E Vaillancourt · 2015 to 2026
$2.8M
NINDS NIH HHS R01 NS052318NINDS NIH HHS T32 NS082168
6 · The paper itself

Abstract

Mobility and memory declines with aging can limit independence. Several single-nucleotide polymorphisms have been associated with cognitive performance, but studies investigating motor function are scant. We examined 4 single-nucleotide polymorphisms involved in dopaminergic metabolism: BDNF (Val66Met), DRD3 (Ser9Gly), DBH (C>T), and COMT (Val158Met) for their relationship to motor and cognitive function in healthy older adults (n = 4605 and n = 7331) who participated in the U.S. Health and Retirement Study. Individuals with genotypes associated with reduced dopamine metabolism exhibited poorer balance and memory. We found the most pronounced effects in the oldest participants (aged 85+ years), supporting the notion that age-related declines in dopamine availability contribute to magnified genotype effects with advancing age. Moreover, males demonstrated stronger associations than did females between a number of beneficial dopamine alleles and cognitive scores, suggesting that sex differences in dopaminergic transmission interact with genotype to influence performance. These findings point to common genetic variants related to dopaminergic metabolism that characterizes individual differences in motor and cognitive function in older adults.

Indexed as

Genetic Association StudiesGenetic MarkersGenotypePolymorphism, Single NucleotideSex CharacteristicsAged, 80 and overBrain-Derived Neurotrophic FactorCatechol O-MethyltransferaseCognitionCognitive DysfunctionDopamineDopamine beta-HydroxylaseDopaminergic NeuronsFemaleForecastingHealthy AgingBrain-Derived Neurotrophic FactorCatechol O-MethyltransferaseCOMT protein, humanDopamineDopamine beta-HydroxylaseDRD3 protein, humanGenetic MarkersReceptors, Dopamine D3BDNFCOMTDBHDRD3GaitMemory

Identifiers

PMID29525179
PMCPMC5924602

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.