ArticleJournal of the American Academy of Dermatology2018
Pathologist characteristics associated with accuracy and reproducibility of melanocytic skin lesion interpretation.
Article in Journal of the American Academy of Dermatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Pigmented Lesion Assay for Suspected Melanoma Lesions: A Health Technology Assessment.Ontario health technology assessment series · 2021Pooled it
- International Skin Imaging Collaboration-Designated Diagnoses (ISIC-DX): Consensus terminology for lesion diagnostic labeling.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Article
- The Implications of a Dermatopathologist's Report on Melanoma Diagnosis and Treatment.Life (Basel, Switzerland) · 2023Article
- Are Pathologists Self-Aware of Their Diagnostic Accuracy? Metacognition and the Diagnostic Process in Pathology.Medical decision making : an international journal of the Society for Medical Decision Making · 2023Article
- High-fidelity detection, subtyping, and localization of five skin neoplasms using supervised and semi-supervised learning.Journal of pathology informatics · 2023Article
- Article
- Assessment of a Diagnostic Classification System for Management of Lesions to Exclude Melanoma.JAMA network open · 2021Article
- Dermoscopic Criteria, Histopathological Correlates and Genetic Findings of Thin Melanoma on Non-Volar Skin.Genes · 2021Review
- Molecular Biomarkers for Melanoma Screening, Diagnosis and Prognosis: Current State and Future Prospects.Frontiers in medicine · 2021Review
- Multiplexed Immunohistochemistry and Digital Pathology as the Foundation for Next-Generation Pathology in Melanoma: Methodological Comparison and Future Clinical Applications.Frontiers in oncology · 2021Review
- MicroRNA Ratios Distinguish Melanomas from Nevi.The Journal of investigative dermatology · 2020Article
- Assessment of Second-Opinion Strategies for Diagnoses of Cutaneous Melanocytic Lesions.JAMA network open · 2019Article
Corrections and comments
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Authors and funding
13 authors at 10 institutions in 2 countries.
Funding
Abstract
backgroundDiagnostic interpretations of melanocytic skin lesions vary widely among pathologists, yet the underlying reasons remain unclear.
objectiveIdentify pathologist characteristics associated with rates of accuracy and reproducibility.
methodsPathologists independently interpreted the same set of biopsy specimens from melanocytic lesions on 2 occasions. Diagnoses were categorized into 1 of 5 classes according to the Melanocytic Pathology Assessment Tool and Hierarchy for Diagnosis system. Reproducibility was determined by pathologists' concordance of diagnoses across 2 occasions. Accuracy was defined by concordance with a consensus reference standard. Associations of pathologist characteristics with reproducibility and accuracy were assessed individually and in multivariable logistic regression models.
resultsRates of diagnostic reproducibility and accuracy were highest among pathologists with board certification and/or fellowship training in dermatopathology and in those with 5 or more years of experience. In addition, accuracy was high among pathologists with a higher proportion of melanocytic lesions in their caseload composition and higher volume of melanocytic lesions. LIMITATIONS: Data gathered in a test set situation by using a classification tool not currently in clinical use.
conclusionDiagnoses are more accurate among pathologists with specialty training and those with more experience interpreting melanocytic lesions. These findings support the practice of referring difficult cases to more experienced pathologists to improve diagnostic accuracy, although the impact of these referrals on patient outcomes requires additional research.
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