Evidence map›Paper›PMID 29524567›Full record

ArticleExperimental hematology2018

PD-1 deficiency augments bone marrow failure in a minor-histocompatibility antigen mismatch lymphocyte infusion model.

Maile K Hollinger, Valentina Giudice, Nicole A Cummings, Guillermo Rivell, Hansheng Zhang, Sachiko Kajigaya, Keyvan Keyvanfar, Jichun Chen, Xingmin Feng, Neal S Young

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental hematology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Maile K HollingerHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, MD, USA.
Valentina GiudiceHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, MD, USA.
Nicole A CummingsHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, MD, USA; Department of Epidemiology and Biostatistics, University of Maryland, College Park, MD, USA.
Guillermo RivellHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, MD, USA; Department of Medicine, Georgetown School of Medicine, Washington, DC, USA.
Hansheng ZhangHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, MD, USA; Department of Epidemiology and Biostatistics, University of Maryland, College Park, MD, USA.
Sachiko KajigayaHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, MD, USA.
Keyvan KeyvanfarHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, MD, USA.
Jichun ChenHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, MD, USA.
Xingmin FengHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, MD, USA. Electronic address: fengx2@nhlbi.nih.gov.
Neal S YoungHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, MD, USA.
National Institutes of Health · USNational Heart Lung and Blood Institute · USUniversity of Maryland, College Park · US

Funding

Pathogenesis And Treatment Of Aplastic AnemiaZIAHL002315 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI YOUNG, NEAL S · 2009 to 2025
$60.1M
NHLBI Animal Program DivisionZIGHL006020 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI CLARK, TANNIA · 2009 to 2025
$47.3M
PATHOGENESIS AND TREATMENT OF APLASTIC ANEMIAZ01HL002315 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI YOUNG, NEAL S · 1985 to 2008
$9.5M
University of Chicago Initiative for Maximizing Student Development (IMSD) - Renewal 01R25GM109439 · NIGMS · UNIVERSITY OF CHICAGO · PI SCHWARTZ, NANCY B · 2014 to 2023
$5.7M
Intramural NIH HHS Z01 HL002315NIGMS NIH HHS R25 GM109439
6 · The paper itself

Abstract

Although PD-1 blockade has revolutionized cancer immunotherapy, immune-related adverse events (irAEs) present life-threatening complications. Recent reports of aplastic anemia (AA) as irAEs implicate PD-1/PD-L1 as important in preventing immune-mediated destruction of the hematopoietic niche. Infusion of PD-1-deficient (PD-1 knockout [KO]) lymph node (LN) cells into minor-antigen mismatched mice resulted in early mortality, as well as more severe bone marrow (BM) hypoplasia, anemia, and BM microarchitecture disruption in PD-1 KO LN-infused mice relative to mice that received B6 LN cell infusion. Mice that received PD-1 KO LN cells had more CD8

Indexed as

Anemia, AplasticAnimalsAnimals, CongenicBone MarrowCD8-Positive T-LymphocytesDisease Models, AnimalImmunologic MemoryLymph NodesLymphocyte TransfusionMiceMice, Inbred C57BLMice, KnockoutMinor Histocompatibility AntigensProgrammed Cell Death 1 ReceptorRadiation ChimeraSpleenMinor Histocompatibility AntigensPdcd1 protein, mouseProgrammed Cell Death 1 Receptor

Identifiers

PMID29524567
PMCPMC5962409
OpenAlexW2789392243

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.