Evidence map›Paper›PMID 29524386›Full record

ArticleEuropean journal of pharmacology2018

Acidosis potentiates endothelium-dependent vasorelaxation and gap junction communication in the superior mesenteric artery.

Ipsita Mohanty, Subas Chandra Parija, Sujit Suklabaidya, Satish Rattan

Abstract read
In one paragraph

Article in European journal of pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Ipsita MohantyDepartment of Medicine, Division of Gastroenterology and Hepatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, United States; Department of Pharmacology and Toxicology, College of Veterinary Sciences and Animal Husbandry, Orissa University of Agriculture and Technology, Bhubaneswar 751003, Odisha, India.
Subas Chandra ParijaDepartment of Pharmacology and Toxicology, College of Veterinary Sciences and Animal Husbandry, Orissa University of Agriculture and Technology, Bhubaneswar 751003, Odisha, India.
Sujit SuklabaidyaTumor Microenvironment and Animal Models Laboratory, Institute of Life Sciences, Bhubaneswar, Odisha, India.
Satish RattanDepartment of Medicine, Division of Gastroenterology and Hepatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, United States. Electronic address: satish.rattan@jefferson.edu.
Thomas Jefferson University · USInstitute of Life Sciences · INOdisha University of Agriculture and Technology · IN

Funding

NEUROHUMORAL CONTROL OF INTERNAL ANAL SPINCHTERR01DK035385 · NIDDK · THOMAS JEFFERSON UNIVERSITY · PI RATTAN, SATISH · 1986 to 2020
$7.8M
NIDDK NIH HHS R01 DK035385
6 · The paper itself

Abstract

Extracellular pH is an important physiological determinant of vascular tone that is normally maintained within 7.35-7.45. Any change outside this range leads to severe pathological repercussions. We investigated the unknown effects of extracellular acidosis on relaxation in the superior mesenteric artery (SMA) of goat. SMA rings were employed to maintain isometric contractions at extracellular pH (pH

Indexed as

VasodilationAcidosisAnimalsCell CommunicationCyclic GMPEndothelium, VascularEpoprostenolGap JunctionsGoatsMesenteric Artery, SuperiorNitric OxideNitric Oxide Synthase Type IIICyclic GMPEpoprostenolNitric OxideNitric Oxide Synthase Type IIIConnexinHyperpolarizationSuperior mesenteric arteryVasorelaxation

Identifiers

PMID29524386
PMCPMC5882507
OpenAlexW2793887400

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.