ArticleJournal of biomedical optics2018
In vivo photoacoustic imaging of chorioretinal oxygen gradients.
Article in Journal of biomedical optics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The trial behind it
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Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Quantifying retinal oxygenation and metabolism by phosphorescence lifetime imaging.Experimental eye research · 2025Review
- Multimodal retinal imaging by visible light optical coherence tomography and phosphorescence lifetime ophthalmoscopy in the mouse eye.Neurophotonics · 2025Article
- Multimodal Imaging-Guided Stem Cell Ocular Treatment.ACS nano · 2024Article
- Molecular and cellular imaging of the eye.Biomedical optics express · 2024Review
- Photoacoustic imaging to monitor outcomes during hyperbaric oxygen therapy: validation in a small cohort and case study in a bilateral chronic ischemic wound.Biomedical optics express · 2022Article
- Monitoring peripheral hemodynamic response to changes in blood pressure via photoacoustic imaging.Photoacoustics · 2022Article
- Photoacoustic monitoring of angiogenesis predicts response to therapy in healing wounds.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022Article
- Impact of skin tone on photoacoustic oximetry and tools to minimize bias.Biomedical optics express · 2022Article
- 3D Ultrasound-Guided Photoacoustic Imaging to Monitor the Effects of Suboptimal Tyrosine Kinase Inhibitor Therapy in Pancreatic Tumors.Frontiers in oncology · 2022Article
- Wavelength and pulse energy optimization for detecting hypoxia in photoacoustic imaging of the neonatal brain: a simulation study.Biomedical optics express · 2021Article
- Activatable Carbocyanine Dimers for Photoacoustic and Fluorescent Detection of Protease Activity.ACS sensors · 2021Article
- Article
- Polyacrylamide hydrogel phantoms for performance evaluation of multispectral photoacoustic imaging systems.Photoacoustics · 2021Article
- Advances in Retinal Oximetry.Translational vision science & technology · 2021Review
- Gold nanoparticles to enhance ophthalmic imaging.Biomaterials science · 2021Review
- Retinal safety evaluation of photoacoustic microscopy.Experimental eye research · 2021Article
- High Resolution Multimodal Photoacoustic Microscopy and Optical Coherence Tomography Visualization of Choroidal Vascular Occlusion.International journal of molecular sciences · 2020Article
- Deep learning improves contrast in low-fluence photoacoustic imaging.Biomedical optics express · 2020Article
- Noninvasive staging of pressure ulcers using photoacoustic imaging.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Chorioretinal imaging has a crucial role for the patients with chorioretinal vascular diseases, such as neovascular age-related macular degeneration. Imaging oxygen gradients in the eye could better diagnose and treat ocular diseases. Here, we describe the use of photoacoustic ocular imaging (PAOI) in measuring chorioretinal oxygen saturation (CR - sO2) gradients in New Zealand white rabbits (n = 5) with ocular ischemia. We observed good correlation (R2 = 0.98) between pulse oximetry and PAOI as a function of different oxygen percentages in inhaled air. We then used an established ocular ischemia model in which intraocular pressure is elevated to constrict ocular blood flow, and notice a positive correlation (R2 = 0.92) between the injected volume of phosphate buffered saline (PBS) and intraocular pressure (IOP) as well as a negative correlation (R2 = 0.98) between CR - sO2 and injected volume of PBS. The CR - sO2 was measured before (baseline), during (ischemia), and after the infusion (600-μL PBS). The ischemia-reperfusion model did not affect the measurement of the sO2 using a pulse oximeter on the animal's paw, but the chorioretinal PAOI signal showed a nearly sixfold decrease in CR - sO2 (n = 5, p = 0.00001). We also observe a sixfold decrease in CR - sO2 after significant elevation of IOP during ischemia, with an increase close to baseline during reperfusion. These data suggest that PAOI can detect changes in chorioretinal oxygenation and may be useful for application to imaging oxygen gradients in ocular disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.