ReviewJournal of neuroendocrinology2018
Emerging insights into hypothalamic-pituitary-gonadal axis regulation and interaction with stress signalling.
Review in Journal of neuroendocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
141 citing papers in PubMed, 2 syntheses or guidelines pooled it, 263 citations in OpenAlex.
- Metabolic and bariatric surgery and male endocrine and reproductive health: a GRADE-assessed meta-analysis.Frontiers in nutrition · 2026Pooled it
- Effects of emotions on IVF/ICSI outcomes in infertile women: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2025Pooled it
- Injectable contraceptives differentially affect the hypothalamic-pituitary-gonadal axis and amenorrhea incidence†.Biology of reproduction · 2026Trial
- Melanocortin 4 receptor agonism enhances sexual brain processing in women with hypoactive sexual desire disorder.The Journal of clinical investigation · 2022Trial
- Hiding in plain sight: uncovering the genetic basis of complex phenotypes through low-risk groups.Genetics · 2026Article
- Prenatal road traffic noise impairs early testicular development in Sprague-Dawley offspring: pharmacological rescue by melatonin and edaravone; developmental preservation by environmental enrichment.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Associations Between Different Subtypes of Adverse Childhood Experiences with Reproductive Mood Disorders-a Scoping Review.Current psychiatry reports · 2026Article
- Seasonal fluctuations in the hypothalamic irisin and its correlation with the hypothalamic-pituitary-gonadal -axis activity in male rhesus monkeys (Macaca mulatta).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Reproduction under Siege: How Chronic Stress Hijacks the HPG Axis?Neuroendocrinology · 2026Review
- Impact of clomipramine postnatal exposure on sexual behavior and reproductive organs in female rats: role of sexual experience.Behavioral and brain functions : BBF · 2026Article
- Endocrine disruptions in thermal injuries: exploring immune system interactions.Physiological reviews · 2026Review
- The interplay of Ashwagandha with hormonal dynamics and gut microbiota in women with breast cancer: a tri-axial perspective.Journal of natural medicines · 2026Review
- Molecular evidence for early deuterostome origins of ovarian cell types and neuroendocrine control of reproduction.Nature communications · 2026Article
- Sex Differences in Depression: Adult Cytogenesis as Potential Target for Precision Psychiatry.Cells · 2026Review
- Comprehensive Insight into the Male Dog Reproductive System in Health and Diseases: Developmental, Genetic, and Environmental Factors-Review on Research and Clinical Trials.Veterinary sciences · 2026Review
- Longer duration of amenorrhea is associated with lower delay discounting and less hedonic eating in girls and young women with low-weight eating disorders.Scientific reports · 2026Article
- Macrophage regulation of hypothalamic-pituitary-adrenal and gonadal axis homeostasis and hormonal output.Biomedical journal · 2026Review
- Integrating mechanistic models to decode the GnRH pulse generator in female mice.Journal of molecular endocrinology · 2026Review
- Molecular Mechanisms of Dysregulated LH and FSH Secretion in Human Reproductive Failure.Biomedicines · 2026Review
- HPA/HPG axes dysfunction: assessing the interrelations between diminished ovarian reserve and mental health.Journal of ovarian research · 2026Review
81 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 3 countries.
Funding
Abstract
Reproduction and fertility are regulated via hormones of the hypothalamic-pituitary-gonadal (HPG) axis. Control of this reproductive axis occurs at all levels, including the brain and pituitary, and allows for the promotion or inhibition of gonadal sex steroid secretion and function. In addition to guiding proper gonadal development and function, gonadal sex steroids also act in negative- and positive-feedback loops to regulate reproductive circuitry in the brain, including kisspeptin neurones, thereby modulating overall HPG axis status. Additional regulation is also provided by sex steroids made within the brain, including neuroprogestins. Furthermore, because reproduction and survival need to be coordinated and balanced, the HPG axis is able to modulate (and be modulated by) stress hormone signalling, including cortiscosterone, from the hypothalamic-pituitary-adrenal (HPA) axis. This review covers recent data related to the neural, hormonal and stress regulation of the HPG axis and emerging interactions between the HPG and HPA axes, focusing on actions at the level of the brain and pituitary.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.