Evidence map›Paper›PMID 29524207›Full record

ArticleInternational journal of cancer2018

MRI background parenchymal enhancement, breast density and serum hormones in postmenopausal women.

Jennifer D Brooks, Janice S Sung, Malcolm C Pike, Irene Orlow, Frank Z Stanczyk, Jonine L Bernstein, Elizabeth A Morris

Open access · hybridAbstract read
In one paragraph

Article in International journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
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  18. Inter-Individual Variation in Response to Estrogen in Human Breast Explants.Journal of mammary gland biology and neoplasia · 2020
    Article
  19. Background parenchymal enhancement on breast MRI: A comprehensive review.Journal of magnetic resonance imaging : JMRI · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jennifer D BrooksDalla Lana School of Public Health Sciences, University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-7574-4256
Janice S SungDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY.
Malcolm C PikeDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0003-4891-1199
Irene OrlowDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
Frank Z StanczykDepartment of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Jonine L BernsteinDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
Elizabeth A MorrisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY.
Memorial Sloan Kettering Cancer Center · USUniversity of Southern California · USUniversity of Toronto · CA

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
MRI Background Parenchymal Enhancement as a Risk Factor for Breast CancerR01CA183086 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI BERNSTEIN, JONINE L., PIKE, MALCOLM C · 2014 to 2016
$2.1M
Epidemiology of MRI parenchymal enhancement: A new marker of breast cancer riskR03CA162207 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI BROOKS, JENNIFER DALLAS · 2012 to 2013
$177k
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA183086NCI NIH HHS R03 CA162207
6 · The paper itself

Abstract

Background parenchymal enhancement (BPE) is the degree to which normal breast tissue enhances on contrast-enhanced magnetic resonance imaging (MRI). MRI-density is a volumetric measure of breast density that is highly correlated with mammographic density, an established breast cancer risk factor. Endogenous estrogen concentrations are positively associated with postmenopausal breast cancer risk and BPE has been shown to be sensitive to hormonal exposures. The objective of our study was to examine the relationship between BPE and MRI-density and serum hormone concentrations in postmenopausal women. This was a study of cancer-free postmenopausal women undergoing contrast-enhanced breast MRI (N = 118). At the time of MRI all women completed a self-administered questionnaire and blood samples were collected for hormone analyses. Serum concentrations of estrone (E1), estradiol (E2) and bioavailable E2 were examined by category of BPE and MRI-density. Compared to women with "minimal" BPE, those who had "marked" BPE had significantly higher serum concentrations of E1, E2 and bioavailable E2 (90% increase, p

Indexed as

Breast DensityContrast MediaBiological AvailabilityBody Mass IndexEstradiolEstroneFemaleHumansMagnetic Resonance ImagingMiddle AgedPostmenopauseSurveys and QuestionnairesContrast MediaEstradiolEstronebackground parenchymal enhancementbreast cancerhormonesMRI

Identifiers

PMID29524207
PMCPMC6041161
OpenAlexW2791979376

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.