ArticleThe Journal of comparative neurology2018
Organization of afferents to the orbitofrontal cortex in the rat.
Article in The Journal of comparative neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Structural and functional organization of the midline and intralaminar nuclei of the thalamus.Frontiers in behavioral neuroscience · 2022Pooled it
- Role of submedius thalamus and its interaction with orbitofrontal cortex in incubation of oxycodone craving.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Submedius thalamic inputs shape the presynaptic architecture of layer 5 orbitofrontal cortex in mice.iScience · 2026Article
- Functional connectome fingerprinting related to BMI and its association with impulsivity.Brain imaging and behavior · 2025Article
- Complementary yet Dissociable Influences of Medial and Lateral Orbitofrontal Cortex over Cue-Guided Decisions Involving Reward Magnitude and Uncertainty.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Activity of CaMKII-expressing neurons in medial prefrontal cortex of male and female Long-Evans rats is necessary for encoding odor information and novelty recognition in an odor-based incidental memory test.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- A new map of the rat isocortex and proisocortex: cytoarchitecture and MBrain structure & function · 2024Article
- Offline orbitofrontal cortex reactivation depends on recency of place-reward changes and coheres with hippocampal replay.iScience · 2024Article
- A goal pointer for a cognitive map in the orbitofrontal cortex.Current opinion in neurobiology · 2023Review
- Social play behavior shapes the development of prefrontal inhibition in a region-specific manner.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- GluN2B inhibition confers resilience against long-term cocaine-induced neurocognitive sequelae.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- The rostral intralaminar nuclear complex of the thalamus supports striatally mediated action reinforcement.eLife · 2023Article
- Projections from the five divisions of the orbital cortex to the thalamus in the rat.The Journal of comparative neurology · 2023Article
- Astrocytes mediate long-lasting synaptic regulation of ventral tegmental area dopamine neurons.Nature neuroscience · 2022Article
- The roles of rat medial prefrontal and orbitofrontal cortices in relapse to cocaine-seeking: A comparison across methods for identifying neurocircuits.Addiction neuroscience · 2022Article
- Midbrain dopamine neurons arbiter OCD-like behavior.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Orbitofrontal cortex populations are differentially recruited to support actions.Current biology : CB · 2022Article
- Thalamic regulation of frontal interactions in human cognitive flexibility.PLoS computational biology · 2022Article
- Top-down projections of the prefrontal cortex to the ventral tegmental area, laterodorsal tegmental nucleus, and median raphe nucleus.Brain structure & function · 2022Article
- Molecular cell identities in the mediodorsal thalamus of infant mice and marmoset.The Journal of comparative neurology · 2022Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
The prefrontal cortex (PFC) is usually defined as the frontal cortical area receiving a mediodorsal thalamic (MD) innervation. Certain areas in the medial wall of the rat frontal area receive a MD innervation. A second frontal area that is the target of MD projections is located dorsal to the rhinal sulcus and often referred to as the orbitofrontal cortex (OFC). Both the medial PFC and OFC are comprised of a large number of cytoarchitectonic regions. We assessed the afferent innervation of the different areas of the OFC, with a focus on projections arising from the mediodorsal thalamic nucleus, the basolateral nucleus of the amygdala, and the midbrain dopamine neurons. Although there are specific inputs to various OFC areas, a simplified organizational scheme could be defined, with the medial areas of the OFC receiving thalamic inputs, the lateral areas of the OFC being the recipient of amygdala afferents, and a central zone that was the target of midbrain dopamine neurons. Anterograde tracer data were consistent with this organization of afferents, and revealed that the OFC inputs from these three subcortical sites were largely spatially segregated. This spatial segregation suggests that the central portion of the OFC (pregenual agranular insular cortex) is the only OFC region that is a prefrontal cortical area, analogous to the prelimbic cortex in the medial prefrontal cortex. These findings highlight the heterogeneity of the OFC, and suggest possible functional attributes of the three different OFC areas.
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