Evidence map›Paper›PMID 29524189›Full record

ArticleDiabetes therapy : research, treatment and education of diabetes and related disorders2018

Perspectives of Patients with Insulin-Treated Type 1 and Type 2 Diabetes on Hypoglycemia: Results of the HAT Observational Study in Central and Eastern European Countries.

Martin Haluzik, Adam Kretowski, Krzysztof Strojek, Leszek Czupryniak, Andrej Janez, Peter Kempler, Michal Andel, Tsvetalina Tankova, Mihail Boyanov, Lea Smircic Duvnjak and 4 more

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In one paragraph

Article in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01696266 (An International Survey on Hypoglycaemia Among Insulin-treated Patients With Diabetes), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01696266 completednot on this map

An International Survey on Hypoglycaemia Among Insulin-treated Patients With Diabetes

TypeobservationalSponsorNovo Nordisk A/SRan2012 to 2013Enrolled29,304ConditionsDiabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2ArmsNo treatment given
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Results of Insulin Therapy in Type 2 Diabetes Mellitus Patients in the Czech Republic: Do They Reflect the Current Status in Other Countries?Diabetes therapy : research, treatment and education of diabetes and related disorders · 2019
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Martin HaluzikDiabetes Centre and Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21, Prague 4, Czech Republic. halm@ikem.cz.ORCID http://orcid.org/0000-0002-0201-6888
Adam KretowskiDepartment of Endocrinology, Diabetology and Internal Diseases, Medical University of Białystok, Białystok, Poland.
Krzysztof StrojekDepartment of Internal Diseases Diabetology and Cardiometabolic Diseases, School of Medicine with the Division of Dentistry (SMDZ) in Zabrze, Medical University of Silesia, Katowice, Poland.
Leszek CzupryniakDepartment of Diabetology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
Andrej JanezDepartment of Endocrinology, Diabetes and Metabolic Diseases, University Medical Center, Ljubljana, Slovenia.
Peter KemplerFirst Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Michal AndelCenter for Research of Nutrition, Metabolism and Diabetes, Third Faculty of Medicine, Charles University, Prague, Czech Republic.
Tsvetalina TankovaClinical Center of Endocrinology, Medical University-Sofia, Sofia, Bulgaria.
Mihail BoyanovClinic of Endocrinology and Metabolism, Department of Internal Medicine, University Hospital Alexandrovska, Medical University-Sofia, Sofia, Bulgaria.
Lea Smircic DuvnjakVuk Vrhovac University Clinic for Diabetes-UH Merkur, School of Medicine, University of Zagreb, Zagreb, Croatia.
Laszlo MadacsyFirst Department of Pediatrics, Faculty of Medicine, Semmelweis University Budapest, Budapest, Hungary.
Iwona TarnowskaNovo Nordisk Pharma, Warsaw, Poland.
Marcin ZychmaNovo Nordisk Pharma, Warsaw, Poland.
Nebojsa LalicClinic for Endocrinology Diabetes and Metabolic Diseases, Clinical Center of Serbia (CCS), Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of this study was to determine the level of awareness of hypoglycemia, the level of fear for hypoglycemia, and the response to hypoglycemic events among insulin-treated diabetes patients from Central and Eastern Europe (CEE). The impact of hypoglycemia on the use of healthcare resources and patient productivity was also assessed.

methodsThis was a multicenter, non-interventional, two-part, patient self-reported questionnaire study that comprised both a retrospective cross-sectional evaluation and a prospective observational evaluation. Study participants were insulin-treated adult patients with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) from CEE.

resultsMost patients (85.4% T1DM and 83.6% T2DM) reported normal hypoglycemia awareness. The median hypoglycemia fear score was 5 out of 10 for T1DM and 4 out of 10 for T2DM patients. Patients increased glucose monitoring, consulted a doctor/nurse, and/or reduced the insulin dose in response to hypoglycemia. As a consequence of hypoglycemia, patients took leave from work/studies or arrived late and/or left early. Hospitalization was required for 31 (1.2%) patients with T1DM and 66 (2.1%) patients with T2DM.

conclusionHypoglycemia impacts patients' personal and social functioning, reduces productivity, and results in additional costs, both direct (related to increased use of healthcare resources) and indirect (related to absenteeism.

fundingNovo Nordisk.

Indexed as

DiabetesHealthcare costsHypoglycemiaHypoglycemia fearInsulin therapy

Identifiers

PMID29524189
PMCPMC6104285

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.