Evidence map›Paper›PMID 29524025›Full record

Trial reportClinical oral investigations2018

Root-end surgery with leucocyte- and platelet-rich fibrin and an occlusive membrane: a randomized controlled clinical trial on patients' quality of life.

Nastaran Meschi, Steffen Fieuws, Anke Vanhoenacker, Olaf Strijbos, Dominique Van der Veken, Constantinus Politis, Paul Lambrechts

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nastaran MeschiDepartment of Oral Health Sciences, Endodontology, KU Leuven & Dentistry, University Hospitals Leuven, Kapucijnenvoer 7 blok a- box 7001, 3000 Leuven, Belgium. nastaran.meschi@kuleuven.be.ORCID http://orcid.org/0000-0003-3537-8831
Steffen FieuwsLeuven Biostatistics and Statistical Bioinformatics Centre, KU Leuven, University of Leuven, Kapucijnenvoer 35 blok d - box 7001, 3000, Leuven, Belgium.
Anke VanhoenackerStomatology and Maxillofacial Surgery, KU Leuven & Dentistry, University Hospitals Leuven, Kapucijnenvoer 7 blok a - box 7001, 3000, Leuven, Belgium.
Olaf StrijbosDepartment of Oral Health Sciences, Endodontology, KU Leuven & Dentistry, University Hospitals Leuven, Kapucijnenvoer 7 blok a- box 7001, 3000 Leuven, Belgium.
Dominique Van der VekenDepartment of Oral Health Sciences, Endodontology, KU Leuven & Dentistry, University Hospitals Leuven, Kapucijnenvoer 7 blok a- box 7001, 3000 Leuven, Belgium.
Constantinus PolitisStomatology and Maxillofacial Surgery, KU Leuven & Dentistry, University Hospitals Leuven, Kapucijnenvoer 7 blok a - box 7001, 3000, Leuven, Belgium.
Paul LambrechtsDepartment of Oral Health Sciences, Endodontology, KU Leuven & Dentistry, University Hospitals Leuven, Kapucijnenvoer 7 blok a- box 7001, 3000 Leuven, Belgium.
KU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study was to investigate the impact of the adjunct of leukocyte- and platelet-rich fibrin (LPRF) to root-end surgery (RES) on the patients' quality of life during the first week post RES. MATERIALS AND

methodsPatients in need of RES were recruited for an open randomized controlled clinical trial (RCT) with a 2 × 2 factorial design. They were randomly allocated to the test (+LPRF) and control (-LPRF) group. Each group was subsequently divided into two strata: with or without an occlusive membrane (Bio-Gide®, Geistlich Biomaterials, Switzerland; BG). After RES, the patients completed daily for 1 week a visual analog pain scale (VAS) and a 5-point Likert-type scale questionnaire concerning activity impairment, occurrence of symptoms, and medication use.

resultsFifty patients were included, equally divided between the test and control group. Only one patient in the "-LPRF+BG-group" had to take additional antibiotics due to a persistent jaw swelling. There was no evidence (p ≤ 0.05) for a difference between the test and control group in VAS, occurrence of pain symptoms, impairment of daily activities, and medication use, over the 7 days and daily during the 7 days post RES.

conclusionsThere was no statistical significant evidence for improvement of patients' quality of life during the first week post RES with LPRF in comparison with RES without LPRF. CLINICAL RELEVANCE: Although LPRF seems to be an inexpensive and autologous agent to reduce pain and swelling post RES, this RCT does not provide a statistical significant evidence for that.

Indexed as

LeukocytesPlatelet-Rich FibrinQuality of LifeAdultCollagenFemaleHumansMaleMicrosurgeryMiddle AgedPain MeasurementPeriapical DiseasesPostoperative ComplicationsSurgical FlapsTooth RootTreatment OutcomeBio-GideCollagenBlood plateletsCystsEndodonticsMembranesPeriapical periodontitis

Identifiers

PMID29524025
OpenAlexW2790805641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.