Evidence map›Paper›PMID 29523926›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2018

Parametric mapping using spectral analysis for

Zhen Fan, Melanie Dani, Grazia D Femminella, Melanie Wood, Valeria Calsolaro, Mattia Veronese, Federico Turkheimer, Steve Gentleman, David J Brooks, Rainer Hinz and 1 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Kinetic evaluation and assessment of longitudinal changes in reference region and extracerebral [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  2. Review
  3. Review
  4. Review
  5. Novel Tracers and Radionuclides in PET Imaging.Radiologic clinics of North America · 2021
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Assessment of simplified methods for quantification of [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Zhen FanDepartment of Medicine, Neurology Imaging Unit, Imperial College London, London, W12 0NN, UK.
Melanie DaniDepartment of Medicine, Neurology Imaging Unit, Imperial College London, London, W12 0NN, UK.
Grazia D FemminellaDepartment of Medicine, Neurology Imaging Unit, Imperial College London, London, W12 0NN, UK.
Melanie WoodDepartment of Medicine, Neurology Imaging Unit, Imperial College London, London, W12 0NN, UK.
Valeria CalsolaroDepartment of Medicine, Neurology Imaging Unit, Imperial College London, London, W12 0NN, UK.
Mattia VeroneseDepartment of Neuroimaging, Institute of Psychiatry, Kings College London, London, WC2R 2LS, UK.
Federico TurkheimerDepartment of Neuroimaging, Institute of Psychiatry, Kings College London, London, WC2R 2LS, UK.
Steve GentlemanDepartment of Medicine, Neurology Imaging Unit, Imperial College London, London, W12 0NN, UK.
David J BrooksDepartment of Medicine, Neurology Imaging Unit, Imperial College London, London, W12 0NN, UK.
Rainer HinzWolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.
Paul EdisonDepartment of Medicine, Neurology Imaging Unit, Imperial College London, London, W12 0NN, UK. paul.edison@imperial.ac.uk.ORCID 0000-0002-6551-2002
Imperial College London · GBKing's College London · GBAarhus University · DKUniversity of Manchester · GB

Funding

Medical Research Council G0900891Medical Research Council G1100810Medical Research Council G84/6523Medical Research Council MC_U120036861Medical Research Council MR/N026063/1
6 · The paper itself

Abstract

purposeNeuroinflammation and microglial activation play an important role in amnestic mild cognitive impairment (MCI) and Alzheimer's disease. In this study, we investigated the spatial distribution of neuroinflammation in MCI subjects, using spectral analysis (SA) to generate parametric maps and quantify

methodsThirteen MCI and nine healthy controls were enrolled in this study. Subjects underwent

resultsWith SA, three component peaks were identified in addition to blood volume. The

conclusionsThis study demonstrates for the first time that spectral analysis can be used to generate parametric maps of

Indexed as

PyrimidinesAgedAlzheimer DiseaseCarbon RadioisotopesCognitive DysfunctionFemaleHumansMaleMiddle AgedPositron-Emission TomographyReceptors, GABACarbon-11Carbon Radioisotopes(methyl-(11)C)N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinaminePyrimidinesReceptors, GABATSPO protein, human11C–PBR28Compartmental modellingLogan graphic analysisMCIPETSpectral analysis

Identifiers

PMID29523926
PMCPMC5993844
OpenAlexW2790701018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.