Trial reportScientific reports2018
Physical Exercise and Spatial Training: A Longitudinal Study of Effects on Cognition, Growth Factors, and Hippocampal Plasticity.
Trial report in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Effects of Physical Exercise on Neuroplasticity and Brain Function: A Systematic Review in Human and Animal Studies.Neural plasticity · 2020Pooled it
- Hippocampal subfield plasticity is associated with improved spatial memory.Communications biology · 2024Trial
- Colocalized White Matter Plasticity and Increased Cerebral Blood Flow Mediate the Beneficial Effect of Cardiovascular Exercise on Long-Term Motor Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Trial
- Brain Training Games Enhance Cognitive Function in Healthy Subjects.Medical science monitor basic research · 2018Trial
- Stroboscopic visual training and the brain: a narrative review of neural mechanisms underlying perceptual-cognitive adaptation in interceptive sports.Frontiers in neuroscience · 2026Review
- Distinct aging-related profiles of allocentric knowledge recall following navigation in an immersive, naturalistic, city-like environment.Frontiers in aging neuroscience · 2026Article
- Housing Environmental Enrichment, Lifestyles, and Public Health Indicators of Neurogenesis in Humans: A Pilot Study.International journal of environmental research and public health · 2024Article
- Editorial: Exercise-induced neuroplasticity in neurodegeneration diseases.Frontiers in neuroscience · 2023Article
- Magnetic resonance spectroscopy investigation in the right human hippocampus following spinal cord injury.Frontiers in neurology · 2023Article
- Moderate, intermittent voluntary exercise in a model of Gulf War Illness improves cognitive and mood function with alleviation of activated microglia and astrocytes, and enhanced neurogenesis in the hippocampus.Brain, behavior, and immunity · 2021Article
- The Effects of Acute Cardiovascular Exercise on Memory and Its Associations With Exercise-Induced Increases in Neurotrophic Factors.Frontiers in aging neuroscience · 2021Article
- A Review of Exercise-Induced Neuroplasticity in Ischemic Stroke: Pathology and Mechanisms.Molecular neurobiology · 2020Review
- The Effects of High-intensity Functional Training (HIFT) on Spatial Learning, Visual Pattern Separation and Attention Span in Adolescents.Frontiers in behavioral neuroscience · 2020Article
- Intrinsic Connectivity Changes Mediate the Beneficial Effect of Cardiovascular Exercise on Sustained Visual Attention.Cerebral cortex communications · 2020Article
- Mild Physical Activity Does Not Improve Spatial Learning in a Virtual Environment.Frontiers in behavioral neuroscience · 2020Article
- Forced Physical Training Increases Neuronal Proliferation and Maturation with Their Integration into Normal Circuits in Pilocarpine Induced Status Epilepticus Mice.Neurochemical research · 2019Article
- Hippocampal deficits in neurodevelopmental disorders.Neurobiology of learning and memory · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physical exercise has been suggested to improve cognitive performance through various neurobiological mechanisms, mediated by growth factors such as BDNF, IGF-I, and VEGF. Moreover, animal research has demonstrated that combined physical and cognitive stimulation leads to increased adult neurogenesis as compared to either experimental condition alone. In the present study, we therefore investigated whether a sequential combination of physical and spatial training in young, healthy adults elicits an additive effect on training and transfer gains. To this end, we compared the effects of (i) eight 20-minute sessions of cycling, (ii) sixteen 30-minute sessions of spatial training, (iii) a combination of both, and included (iv) a passive control cohort. We assessed longitudinal changes in cognitive performance, growth factor levels, and T
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.