ArticleScientific reports2018
A Novel Role of Irbesartan in Gastroprotection against Indomethacin-Induced Gastric Injury in Rats: Targeting DDAH/ADMA and EGFR/ERK Signaling.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
- Antiulcer activity ofOpen veterinary journal · 2025Review
- Gastroprotective Effect of Linagliptin on Indomethacin-Induced Gastric Ulceration in Mice: Crosstalk Between Oxidative Stress and Inflammasome Pathways.ACS pharmacology & translational science · 2025Article
- Protective effect of irbesartan against hepatic ischemia-reperfusion injury in rats: role of ERK, STAT3, and PPAR-γ inflammatory pathways in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Combined effect of pantoprazole and mesenchymal stem cells on experimentally induced gastric ulcer: implication of oxidative stress, inflammation and apoptosis pathways.Inflammopharmacology · 2024Article
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- Article
- Angiotensin Regulation of Vascular Homeostasis: Exploring the Role of ROS and RAS Blockers.International journal of molecular sciences · 2023Review
- The Protective Effect of Walnut Oligopeptides against Indomethacin-Induced Gastric Ulcer in Rats.Nutrients · 2023Article
- Gastroprotective effect of zafirlukast against indomethacin induced gastric ulcer in rats via PGE2 and anti-inflammatory pathways.Iranian journal of basic medical sciences · 2023Article
- Irbesartan ameliorates inflammation via transendothelial leukocyte migration due to VCAM-1/NOX-1 signaling in cisplatin-induced cardiotoxicity.Iranian journal of basic medical sciences · 2023Article
- The Effect of Metformin on Ethanol- and IndomethacinInduced Gastric Ulcers in Rats.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022Article
- Potential Active Constituents fromPharmaceuticals (Basel, Switzerland) · 2022Article
- Gastroprotective Effect ofArchives of Razi Institute · 2022Article
- Curcumin ameliorated low dose-Bisphenol A induced gastric toxicity in adult albino rats.Scientific reports · 2022Article
- DDAH1 Promotes Lung Endothelial Barrier Repair by Decreasing Leukocyte Transendothelial Migration and Oxidative Stress in Explosion-Induced Lung Injury.Oxidative medicine and cellular longevity · 2022Article
- DDAH-1, via regulation of ADMA levels, protects against ischemia-induced blood-brain barrier leakage.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- On the Rational Drug Design for Hypertension through NMR Spectroscopy.Molecules (Basel, Switzerland) · 2020Review
- Gastroprotective effects of both aqueous and ethanolic extracts ofIranian journal of basic medical sciences · 2020Article
- Curcumin attenuates endothelial cell fibrosis through inhibiting endothelial-interstitial transformation.Clinical and experimental pharmacology & physiology · 2020Article
- (E)-2-Cyano-3-(1International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The advent of angiotensin II type 1 receptor blockers (ARBs) as intriguing gastroprotective candidates and the superior pharmacokinetics and pharmacodynamics displayed by irbesartan compared to many other ARBs raised the interest to investigate its gastroprotective potential in a rat model of gastric injury. Irbesartan (50 mg/Kg) was orally administered to male Wistar rats once daily for 14 days; thereafter gastric injury was induced by indomethacin (60 mg/Kg, p.o). Irbesartan reduced gastric ulcer index, gastric acidity, and ameliorated indomethacin-induced gastric mucosal apoptotic and inflammatory aberrations, as demonstrated by hampering caspase-3, prostaglandin E
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