ArticleNature communications2018
Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
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- A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy.American journal of human genetics · 2024Article
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- The Prolonged Treatment ofInternational journal of molecular sciences · 2023Article
- BurkHostGEN: a study protocol for evaluating variations in theWellcome open research · 2023Article
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- Genetic Susceptibility to Enteric Fever in Experimentally Challenged Human Volunteers.Infection and immunity · 2022Article
- ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice.PLoS pathogens · 2021Article
- These Are the Genes You're Looking For: Finding Host Resistance Genes.Trends in microbiology · 2021Review
- Host genetics and infectious disease: new tools, insights and translational opportunities.Nature reviews. Genetics · 2021Review
- AlteredFrontiers in immunology · 2021Article
- Pathogenic signature of invasive non-typhoidalHuman vaccines & immunotherapeutics · 2020Review
- Genetic variation in the MacAB-TolC efflux pump influences pathogenesis of invasive Salmonella isolates from Africa.PLoS pathogens · 2020Article
- HumanClinical & translational immunology · 2020Article
- A Loss-of-Function Mutation in the Integrin Alpha L (Infection and immunity · 2019Article
- Using a Systems Biology Approach To Study Host-Pathogen Interactions.Microbiology spectrum · 2019Review
- Current Understanding of Innate Immune Cell Dysfunction in Childhood Undernutrition.Frontiers in immunology · 2019Review
- Invasive NontyphoidalEcoSal Plus · 2019Review
- The critical needs and challenges for genetic architecture studies in Africa.Current opinion in genetics & development · 2018Review
Corrections and comments
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Authors and funding
22 authors at 4 institutions in 4 countries.
Funding
Abstract
Nontyphoidal Salmonella (NTS) is a major cause of bacteraemia in Africa. The disease typically affects HIV-infected individuals and young children, causing substantial morbidity and mortality. Here we present a genome-wide association study (180 cases, 2677 controls) and replication analysis of NTS bacteraemia in Kenyan and Malawian children. We identify a locus in STAT4, rs13390936, associated with NTS bacteraemia. rs13390936 is a context-specific expression quantitative trait locus for STAT4 RNA expression, and individuals carrying the NTS-risk genotype demonstrate decreased interferon-γ (IFNγ) production in stimulated natural killer cells, and decreased circulating IFNγ concentrations during acute NTS bacteraemia. The NTS-risk allele at rs13390936 is associated with protection against a range of autoimmune diseases. These data implicate interleukin-12-dependent IFNγ-mediated immunity as a determinant of invasive NTS disease in African children, and highlight the shared genetic architecture of infectious and autoimmune disease.
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Registered trials
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