Evidence map›Paper›PMID 29523648›Full record

ArticleEMBO reports2018

Quorum-sensing regulator RhlR but not its autoinducer RhlI enables

Samantha Haller, Adrien Franchet, Abdul Hakkim, Jing Chen, Eliana Drenkard, Shen Yu, Stefanie Schirmeier, Zi Li, Nelson Martins, Frederick M Ausubel and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in EMBO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. α2-macroglobulin function of thioester-containing proteins guardsProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  9. Growth deregulation and interaction with host hemocytes contribute to tumor progression in a Drosophila brain tumor model.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Article
  11. Article
  12. Recent Advance in Small Molecules Targeting RhlR ofAntibiotics (Basel, Switzerland) · 2022
    Review
  13. Review
  14. Phagocytosis Is the Sole Arm ofFrontiers in immunology · 2022
    Article
  15. Frontiers in immunology · 2022
    Review
  16. Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Samantha HallerCNRS, M3I UPR 9022, Université de Strasbourg, Strasbourg, France.
Adrien FranchetCNRS, M3I UPR 9022, Université de Strasbourg, Strasbourg, France.
Abdul HakkimDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4426-2585
Jing ChenSino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou, China.
Eliana DrenkardDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Shen YuDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Stefanie SchirmeierCNRS, M3I UPR 9022, Université de Strasbourg, Strasbourg, France.
Zi LiSino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou, China.
Nelson MartinsCNRS, M3I UPR 9022, Université de Strasbourg, Strasbourg, France.
Frederick M AusubelDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Samuel LiégeoisCNRS, M3I UPR 9022, Université de Strasbourg, Strasbourg, France.
Dominique FerrandonCNRS, M3I UPR 9022, Université de Strasbourg, Strasbourg, France d.ferrandon@ibmc-cnrs.unistra.fr.ORCID 0000-0001-7680-7773
Centre National de la Recherche Scientifique · FRHarvard University · USGuangzhou Medical University · CN

Funding

Identifying novel anti-infectives by high through-put screening in whole animalsR01AI085581 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI AUSUBEL, FREDERICK M · 2009 to 2013
$4.7M
NIAID NIH HHS R01 AI085581
6 · The paper itself

Abstract

When

Indexed as

PhagocytosisAnimalsBacterial ProteinsCaenorhabditis elegansDEAD-box RNA HelicasesDrosophila melanogasterDrosophila ProteinsGene Expression Regulation, BacterialIntestinesLigasesPseudomonas aeruginosaQuorum SensingReceptors, Pattern RecognitionTranscription FactorsVirulenceBacterial ProteinsDEAD-box RNA HelicasesDrosophila ProteinsLigasesReceptors, Pattern RecognitionRHLI protein, Pseudomonas aeruginosaRhlR protein, Pseudomonas aeruginosathioester-containing protein-4, DrosophilaTranscription Factorscompetition opsonization‐detection by pattern recognition receptorsinfection routeintestinal infectionphagocytosisquorum sensing

Identifiers

PMID29523648
PMCPMC5934776
OpenAlexW2790781605

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.