Evidence map›Paper›PMID 29523447›Full record

ReviewSeminars in perinatology2018

Adverse outcomes of pregnancy-associated Zika virus infection.

William J Britt

Abstract readReview
In one paragraph

Review in Seminars in perinatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Pregnancy in the Shadow of Covid-19: A Qualitative Study.Health expectations : an international journal of public participation in health care and health policy · 2026
    Article
  2. Article
  3. Viral Infections During Pregnancy: The Big Challenge Threatening Maternal and Fetal Health.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2022
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Modeling Zika Virus-Associated Birth Defects in Nonhuman Primates.Journal of the Pediatric Infectious Diseases Society · 2018
    Review
  10. Zika virus: epidemiology, clinical aspects, diagnosis, and control of infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

William J BrittDepartment of Pediatrics, University of Alabama School of Medicine, Childrens Hospital Harbor Bldg 160, Birmingham, AL 35233. Electronic address: wbritt@peds.uab.edu.

Funding

CMV Vaccines: Reinfection and Antigenic Variation (Vision and auditory screening in infants born to women enrolled in ZIP)R01HD061959 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRITT, WILLIAM JARVIS, MUSSI-PINHATA, MARISA MARCIA · 2011 to 2023
$5.9M
CMV Vaccines: Reinfection and Antigenic VariationR01AI049537 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRITT, WILLIAM JARVIS · 2002 to 2007
$1.1M
NIAID NIH HHS R01 AI049537NICHD NIH HHS R01 HD061959
6 · The paper itself

Abstract

The spread of Zika virus to the Americas was accompanied by surge in the number of infants with CNS abnormalities leading to a declaration of a health emergency by the WHO. This was accompanied by significant responses from governmental health agencies in the United States and Europe that resulted in significant new information described in the natural history of this perinatal infection in a very short period of time. Although much has been learned about Zika virus infection during pregnancy, limitations of current diagnostics and the challenges for accurate serologic diagnosis of acute Zika virus infection has restricted our understanding of the natural history of this perinatal infection to infants born to women with clinical disease during pregnancy and to Zika exposed infants with obvious clinical stigmata of disease. Thus, the spectrum of disease in infants exposed to Zika virus during pregnancy remains to be defined. In contrast, observations in informative animal models of Zika virus infections have provided rational pathways for vaccine development and existing antiviral drug development programs for other flaviviruses have resulted in accelerated development for potential antiviral therapies. This brief review will highlight some of the current concepts of the natural history of Zika virus during pregnancy.

Indexed as

AnimalsAntiviral AgentsBrain DiseasesDisease Models, AnimalFemaleHumansInfant, NewbornMicrocephalyPregnancyPregnancy Complications, InfectiousSouth AmericaViral VaccinesZika VirusZika Virus InfectionAntiviral AgentsViral VaccinesCongenital Zika virus infectionZika associated adverse outcomes of pregnancyZika virus

Identifiers

PMID29523447
PMCPMC7442220

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.