ArticleImmunity2018
Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8
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Article in Immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
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112citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
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Who cites it
112 citing papers in PubMed, 200 citations in OpenAlex.
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- Boosting T cell antioxidant capacity: A strategic approach to overcome immunosuppression in solid tumors.Redox biology · 2026Review
- Targeting colorectal cancer and T‑cell metabolism for the treatment of colorectal cancer (Review).Oncology reports · 2026Review
- Spatial architecture of immunometabolism: Mitochondrial‑organelle interfaces in immune signaling (Review).International journal of molecular medicine · 2026Review
- GRP75 sustains CD8Cell death and differentiation · 2026Article
- Mitochondria-Associated Endoplasmic Reticulum Membranes in Cancer: Hubs for Tumor Progression and Therapeutic Vulnerabilities.Cell biology international · 2026Review
- T-Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan-Cancer Characteristics, and Therapeutic Interventions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Immunomodulatory supramolecular hydrogel for rheumatoid arthritis management via adenosine A2A receptor-mediated macrophage remodeling.Bioactive materials · 2026Article
- The spatiotemporal dynamics of MAMs: mechanisms, pathologies, and therapeutic rewiring.Cellular & molecular biology letters · 2026Review
- Targeting organelle function in T cells for cancer immunotherapy.Nature reviews. Immunology · 2026Review
- Single-cell transcriptomic analysis and machine learning identify ATAD3A as a key gene that stabilizes mitochondrial-endoplasmic reticulum membranes, promoting bladder cancer progression.Journal of translational medicine · 2026Article
- Multiplexed high-content imaging uncovers morphological diversity of lymphocyte activation and dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Gambogenic acid ameliorates inflammation by inhibiting HK1-mediated Warburg effect and NLRP3 inflammasome activation in sepsis.Acta pharmaceutica Sinica. B · 2026Article
- Supercharging the metabolic engine: mitochondrial engineering strategies for CAR-T persistence in solid tumors.Frontiers in immunology · 2026Review
- mTOR signaling networks: mechanistic insights and translational frontiers in disease therapeutics.Signal transduction and targeted therapy · 2025Review
- Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Mitochondrial Metabolism in T-Cell Exhaustion.International journal of molecular sciences · 2025Review
- The flux of energy in critical illness and the obesity paradox.Physiological reviews · 2025Review
- Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy.Cell metabolism · 2025Article
- Mitochondrial Membrane Potential of CD8Journal of clinical and translational hepatology · 2025Article
52 more citing papers are in PubMed but not listed here.
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Authors and funding
23 authors at 6 institutions in 2 countries.
Glenn R BantugImmunobiology Laboratory, Department of Biomedicine, University and University Hospital of Basel. 20 Hebelstrasse, 4031 Basel, Switzerland.
Marco FischerImmunobiology Laboratory, Department of Biomedicine, University and University Hospital of Basel. 20 Hebelstrasse, 4031 Basel, Switzerland.
Jasmin GrählertImmunobiology Laboratory, Department of Biomedicine, University and University Hospital of Basel. 20 Hebelstrasse, 4031 Basel, Switzerland.
Maria L BalmerImmunobiology Laboratory, Department of Biomedicine, University and University Hospital of Basel. 20 Hebelstrasse, 4031 Basel, Switzerland.
Gunhild UnterstabImmunobiology Laboratory, Department of Biomedicine, University and University Hospital of Basel. 20 Hebelstrasse, 4031 Basel, Switzerland.
Leyla DeveliogluImmunobiology Laboratory, Department of Biomedicine, University and University Hospital of Basel. 20 Hebelstrasse, 4031 Basel, Switzerland.
Rebekah SteinerImmunobiology Laboratory, Department of Biomedicine, University and University Hospital of Basel. 20 Hebelstrasse, 4031 Basel, Switzerland.
Lianjun ZhangLudwig Center for Cancer Research, University of Lausanne. 155 Chemin des Boveresses, Épalinges, 1066 Vaud, Switzerland.
Ana S H CostaMRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, University of Cambridge, Box 197, Cambridge Biomedical Campus, CB2 0XZ Cambridge, UK.
Patrick M GubserImmunobiology Laboratory, Department of Biomedicine, University and University Hospital of Basel. 20 Hebelstrasse, 4031 Basel, Switzerland.
Anne-Valérie BurgenerImmunobiology Laboratory, Department of Biomedicine, University and University Hospital of Basel. 20 Hebelstrasse, 4031 Basel, Switzerland.
Ursula SauderElectron Microscopy Core Facility, Biozentrum, University of Basel, 70 Klingelbergstrasse, 4056 Basel, Switzerland.
Jordan LöligerImmunobiology Laboratory, Department of Biomedicine, University and University Hospital of Basel. 20 Hebelstrasse, 4031 Basel, Switzerland.
Réka BelleImmunobiology Laboratory, Department of Biomedicine, University and University Hospital of Basel. 20 Hebelstrasse, 4031 Basel, Switzerland.
Sarah DimeloeImmunobiology Laboratory, Department of Biomedicine, University and University Hospital of Basel. 20 Hebelstrasse, 4031 Basel, Switzerland.
Jonas LötscherImmunobiology Laboratory, Department of Biomedicine, University and University Hospital of Basel. 20 Hebelstrasse, 4031 Basel, Switzerland.
Annaïse JauchImmunodeficiency Laboratory, Department of Biomedicine, University and University Hospital of Basel, 20 Hebelstrasse, 4031 Basel, Switzerland.
Mike RecherImmunodeficiency Laboratory, Department of Biomedicine, University and University Hospital of Basel, 20 Hebelstrasse, 4031 Basel, Switzerland.
Gideon HöngerImmunobiology Laboratory, Department of Biomedicine, University and University Hospital of Basel. 20 Hebelstrasse, 4031 Basel, Switzerland.
Michael N HallBiozentrum, University of Basel, 70 Klingelbergstrasse, 4056 Basel, Switzerland.
Pedro RomeroLudwig Center for Cancer Research, University of Lausanne. 155 Chemin des Boveresses, Épalinges, 1066 Vaud, Switzerland.
Christian FrezzaMRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, University of Cambridge, Box 197, Cambridge Biomedical Campus, CB2 0XZ Cambridge, UK.
Christoph HessImmunobiology Laboratory, Department of Biomedicine, University and University Hospital of Basel. 20 Hebelstrasse, 4031 Basel, Switzerland. Electronic address: chess@uhbs.ch.
University Hospital of Basel · CHUniversity of Basel · CHHutchison/MRC Research Centre · GBLudwig Cancer Research · CHUniversity of Cambridge · GBUniversity of Lausanne · CH
Funding
Medical Research Council MC_UU_12022/6
Abstract
Glycolysis is linked to the rapid response of memory CD8
Indexed as
Energy MetabolismImmunologic MemorySignal TransductionCD8-Positive T-LymphocytesCell RespirationEndoplasmic ReticulumGlycogen Synthase Kinase 3 betaGlycolysisIntracellular MembranesLymphocyte ActivationMechanistic Target of Rapamycin Complex 2MitochondriaModels, BiologicalProto-Oncogene Proteins c-aktRapamycin-Insensitive Companion of mTOR ProteinGlycogen Synthase Kinase 3 betaMechanistic Target of Rapamycin Complex 2Proto-Oncogene Proteins c-aktRapamycin-Insensitive Companion of mTOR ProteinAktendoplasmic reticulumglycolysisGSK3-betahexokinaseIFN-gammamemory CD8(+) T cellsmitochondriamTORVDAC
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.