Evidence map›Paper›PMID 29523391›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2018

Value of ictal and interictal epileptiform discharges and high frequency oscillations for delineating the epileptogenic zone in patients with focal cortical dysplasia.

C Cuello-Oderiz, N von Ellenrieder, R Sankhe, A Olivier, J Hall, F Dubeau, J Gotman

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Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  16. Targeting high frequency oscillations in epilepsy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

C Cuello-OderizDepartment of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, 3801 Rue University, Montréal, QC H3A 2B4, Canada. Electronic address: carolinacuellooderiz@gmail.com.
N von EllenriederDepartment of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, 3801 Rue University, Montréal, QC H3A 2B4, Canada. Electronic address: nicolas.vonellenrieder@mcgill.ca.
R SankheMcGill University, 845 Sherbrooke St W, Montréal, QC H3A 0G4, Canada. Electronic address: rmsankhe@gmail.com.
A OlivierDepartment of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, 3801 Rue University, Montréal, QC H3A 2B4, Canada. Electronic address: andre.olivier@mcgill.ca.
J HallDepartment of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, 3801 Rue University, Montréal, QC H3A 2B4, Canada. Electronic address: jeff.hall@mcgill.ca.
F DubeauDepartment of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, 3801 Rue University, Montréal, QC H3A 2B4, Canada. Electronic address: francois.dubeau@mcgill.ca.
J GotmanDepartment of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, 3801 Rue University, Montréal, QC H3A 2B4, Canada. Electronic address: jean.gotman@mcgill.ca.

Funding

CIHR FDN 143208
6 · The paper itself

Abstract

objectivesThere are different neurophysiological markers of the Epileptogenic Zone (EZ), but their sensitivity and specificity for the EZ is not known in Focal Cortical Dysplasia (FCD) patients.

methodsWe studied patients with FCD who underwent stereoelectroencephalography (SEEG) and surgery. We marked in the SEEG: (a) typical and atypical interictal epileptiform patterns, (b) ictal onset patterns, and (c) rates of ripples (80-250 Hz) and fast ripples (FRs) (>250 Hz). High frequency oscillations were marked automatically during one hour of deep sleep. Surgical outcome was defined as good (Engel I) or poor (Engel II-IV). We computed the sensitivity and, as a measure of specificity, the false positive rate to identify the EZ, and compared them across the different neurophysiological markers.

resultsWe studied 21 patients, 19 with FCD II. Ictal and typical interictal pattern were the markers with highest sensitivity, while the atypical interictal pattern had the lowest. We found no significant difference in specificity among markers. However, there is a tendency that FRs had the lowest false positive rate.

conclusionThe typical interictal pattern has the highest sensitivity. The clinical use of FRs is limited by their low sensitivity. SIGNIFICANCE: We suggest to analyze the typical interictal pattern first. FRs should be analyzed in a second step. If, for instance, a focus with FRs and no typical interictal pattern is found, this area could be considered for resection.

Indexed as

AdolescentAdultBrainChildElectroencephalographyEpilepsyFemaleHumansMagnetic Resonance ImagingMaleMalformations of Cortical Development, Group IMiddle AgedRetrospective StudiesSeizuresSensitivity and SpecificityYoung AdultEpilepsyFocal cortical dysplasiaHigh frequency oscillationsMRIStereoelectroencephalography (SEEG)Surgery

Identifiers

PMID29523391

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.