Evidence map›Paper›PMID 29523178›Full record

ArticleEpigenetics & chromatin2018

The bromodomain-containing protein Ibd1 links multiple chromatin-related protein complexes to highly expressed genes in Tetrahymena thermophila.

Alejandro Saettone, Jyoti Garg, Jean-Philippe Lambert, Syed Nabeel-Shah, Marcelo Ponce, Alyson Burtch, Cristina Thuppu Mudalige, Anne-Claude Gingras, Ronald E Pearlman, Jeffrey Fillingham

Open access · goldAbstract read
In one paragraph

Article in Epigenetics & chromatin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  4. Review
  5. Dual modes of DNA NProceedings of the National Academy of Sciences of the United States of America · 2025
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  13. Exploring the Histone Acetylation Cycle in the Protozoan ModelFrontiers in cell and developmental biology · 2020
    Review
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Alejandro SaettoneDepartment of Chemistry and Biology, Ryerson University, 350 Victoria St., Toronto, M5B 2K3, Canada.
Jyoti GargDepartment of Biology, York University, 4700 Keele St., Toronto, M3J 1P3, Canada.
Jean-Philippe LambertLunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Toronto, M5G 1X5, Canada.
Syed Nabeel-ShahDepartment of Chemistry and Biology, Ryerson University, 350 Victoria St., Toronto, M5B 2K3, Canada.
Marcelo PonceSciNet HPC Consortium, University of Toronto, 661 University Ave, Suite 1140, Toronto, M5G 1M1, Canada.
Alyson BurtchDepartment of Chemistry and Biology, Ryerson University, 350 Victoria St., Toronto, M5B 2K3, Canada.
Cristina Thuppu MudaligeDepartment of Chemistry and Biology, Ryerson University, 350 Victoria St., Toronto, M5B 2K3, Canada.
Anne-Claude GingrasLunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Toronto, M5G 1X5, Canada.
Ronald E PearlmanDepartment of Biology, York University, 4700 Keele St., Toronto, M3J 1P3, Canada.
Jeffrey FillinghamDepartment of Chemistry and Biology, Ryerson University, 350 Victoria St., Toronto, M5B 2K3, Canada. Jeffrey.fillingham@ryerson.ca.ORCID 0000-0002-9000-1458
Toronto Metropolitan University · CAMount Sinai Hospital · CAUniversity of Toronto · CAYork University · CA

Funding

CIHR FDN 143301CIHR MOP13347
6 · The paper itself

Abstract

backgroundThe chromatin remodelers of the SWI/SNF family are critical transcriptional regulators. Recognition of lysine acetylation through a bromodomain (BRD) component is key to SWI/SNF function; in most eukaryotes, this function is attributed to SNF2/Brg1.

resultsUsing affinity purification coupled to mass spectrometry (AP-MS) we identified members of a SWI/SNF complex (SWI/SNF

conclusionsOur results suggest that through recognizing specific histones marks, Ibd1 targets active chromatin regions of highly expressed genes in Tetrahymena where it subsequently might coordinate the recruitment of several chromatin-remodeling complexes to regulate the transcriptional landscape of vegetatively growing Tetrahymena cells.

Indexed as

Epigenesis, GeneticGene Expression RegulationGene Expression Regulation, DevelopmentalHistonesMass SpectrometryNuclear ProteinsProteomicsProtozoan ProteinsTetrahymena thermophilaTranscription, GeneticHistonesNuclear ProteinsProtozoan ProteinsBromodomainChromatin-remodeling complexesTetrahymena

Identifiers

PMID29523178
PMCPMC5844071
OpenAlexW2789841853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.