Evidence map›Paper›PMID 29523153›Full record

Observational studyBMC health services research2018

Cost-effectiveness in extracorporeal life support in critically ill adults in the Netherlands.

Annemieke Oude Lansink-Hartgring, Dinis Dos Reis Miranda, Dirk W Donker, Jacinta J Maas, Thijs Delnoij, Marijn Kuijpers, Judith van den Brule, Erik Scholten, Hendrik Endeman, Alexander P J Vlaar and 2 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC health services research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02837419 (A Multicenter Prospective Observational Cohort Study Determining the Cost-effectiveness of Extracorporal Life Support), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02837419 unknown statusnot on this map

A Multicenter Prospective Observational Cohort Study Determining the Cost-effectiveness of Extracorporal Life Support (ECLS) Treatment

Typeobservational_patient_registrySponsorUniversity Medical Center GroningenRan2017 to 2020Enrolled200ConditionsCritically IllArmsHealth related Quality of life EQ-5D
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 26 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Annemieke Oude Lansink-HartgringUniversity Medical Center Groningen, University of Groningen, PO box 30.001, 9700, RB, Groningen, the Netherlands. a.oudelansink@umcg.nl.ORCID 0000-0003-3641-9658
Dinis Dos Reis MirandaErasmus Medical Center Rotterdam, Rotterdam, the Netherlands.
Dirk W DonkerUniversity Medical Center Utrecht, Utrecht, the Netherlands.
Jacinta J MaasLeiden University Medical Center, Leiden, the Netherlands.
Thijs DelnoijMaastricht University Medical Center, Maastricht, the Netherlands.
Marijn KuijpersIsala, Zwolle, the Netherlands.
Judith van den BruleRadboud University Medical Center, Nijmegen, the Netherlands.
Erik ScholtenSint. Antonius Ziekenhuis Nieuwegein, Nieuwegein, the Netherlands.
Hendrik EndemanOnze Lieve Vrouwen Gasthuis, Amsterdam, the Netherlands.
Alexander P J VlaarAmsterdam Medical Center, Amsterdam, the Netherlands.
Walter M van den BerghUniversity Medical Center Groningen, University of Groningen, PO box 30.001, 9700, RB, Groningen, the Netherlands.
Dutch ECLS study group
University Medical Center Groningen · NLLeiden University Medical Center · NLRadboud University Nijmegen · NLErasmus MC · NLMaastricht University · NLOLVG · NLSt. Antonius Ziekenhuis · NL

Funding

ZonMw (NL) 843002801
6 · The paper itself

Abstract

backgroundExtracorporeal life support (ECLS) is used to support the cardiorespiratory function in case of severe cardiac and/or respiratory failure in critically ill patients. According to the ELSO guidelines ECLS should be considered when estimated mortality risk approximates 80%. ECLS seems an efficient therapy in terms of survival benefit, but no undisputed evidence is delivered yet. The aim of the study is to assess the health-related quality of life after ECLS treatment and its cost effectiveness.

methodsWe will perform a prospective observational cohort study. All adult patients who receive ECLS in the participating centers will be included. Exclusion criteria are patients in whom the ECLS is only used to bridge a procedure (like a high risk percutaneous coronary intervention or surgery) or the absence of informed consent. Data collection includes patient characteristics and data specific for ECLS treatment. Severity of illness and mortality risk is measured as precisely as possible using measurements for the appropriate age group and organ failure. For analyses on survival patients will act as their own control as we compare the actual survival with the estimated mortality on initiation of ECLS if conservative treatment would have been continued. Survivors are asked to complete validated questionnaires on health related quality of life (EQ5D-5 L) and on medical consumption and productivity losses (iMTA/iPCQ) at 6 and 12 months. Also the health related quality of life 1 month prior to ECLS initiation will be obtained by a questionnaire, if needed provided by relatives. With an estimated overall survival of 62% 210 patients need to be recruited to make a statement on cost effectiveness for all ECLS indications. DISCUSSION: If our hypothesis that ECLS treatment is cost-effective is confirmed by this prospective study this could lead to an even broader use of ECLS treatment.

trial registrationThe trial is registered at ( NCT02837419 ) registration date July 19, 2016 and with the Dutch trial register, http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=6599.

Indexed as

AdultCost-Benefit AnalysisCritical IllnessExtracorporeal Membrane OxygenationHealth Services ResearchHumansNetherlandsProspective StudiesQuality of LifeSurveys and QuestionnairesTreatment OutcomeCost-effectivenessCritical careExtracorporeal life supportIntensive care unitOutcomeQuality of life

Identifiers

PMID29523153
PMCPMC5845153
OpenAlexW2797313665

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.