ArticleBMC veterinary research2018
Effects of herbal nutraceuticals and/or zinc against Haemonchus contortus in lambs experimentally infected.
Article in BMC veterinary research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Chicory modulates the rumen environment in lambs with endoparasites.Scientific reports · 2025Article
- Growth performance, carcass traits, and histological changes of goats supplemented with different sources of phytochemicals.Scientific reports · 2025Article
- The Anthelmintic Activity ofPathogens (Basel, Switzerland) · 2025Article
- Effect of zinc oxide nanoparticle supplementation on parasite infection and rumen environment of grazing lambs.Frontiers in veterinary science · 2025Article
- Insights into the role of bioactive plants for lambs infected withFrontiers in veterinary science · 2025Article
- Recent Advances in the Control of Endoparasites in Ruminants from a Sustainable Perspective.Pathogens (Basel, Switzerland) · 2023Article
- Characterization of interferon gamma gene in relation to immunological responses in Haemonchus contortus resistant and susceptible Garole sheep.Veterinary research communications · 2023Article
- Antibody response and abomasal histopathology of lambs with haemonchosis during supplementation with medicinal plants and organic selenium.Veterinary and animal science · 2023Article
- DoesHelminthologia · 2022Article
- Impact of Sainfoin (Pathogens (Basel, Switzerland) · 2022Article
- Effects of Medicinal Plants and Organic Selenium against Ovine Haemonchosis.Animals : an open access journal from MDPI · 2021Article
- Effect ofAnimals : an open access journal from MDPI · 2021Article
- Impact of Zinc and/or Herbal Mixture on Ruminal Fermentation, Microbiota, and Histopathology in Lambs.Frontiers in veterinary science · 2021Article
- Does Herbal and/or Zinc Dietary Supplementation Improve the Antioxidant and Mineral Status of Lambs with Parasite Infection?Antioxidants (Basel, Switzerland) · 2020Article
- Influence of metabolizable protein and minerals supplementation on detrimental effects of endoparasitic nematodes infection in small ruminants.Tropical animal health and production · 2020Review
- Anthelmintic Activity of Wormwood (Animals : an open access journal from MDPI · 2020Article
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- Natural chemotherapeutic alternatives for controlling of haemonchosis in sheep.BMC veterinary research · 2019Article
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe gastrointestinal parasitic nematode Haemonchus contortus is a pathogenic organism resistant to several anthelmintics. This study assessed the efficacy of a medicinal herbal mixture (Herbmix) and organic zinc, as an essential trace element for the proper functioning of both unspecific and specific immune defensive mechanisms, against experimental infections with H. contortus in lambs. All lambs were infected orally with approximately 5000 third-stage larvae of a strain of H. contortus susceptible to anthelmintics (MHco1). Twenty-four female lambs 3-4 months of age were divided into four groups: unsupplemented animals (control), animals supplemented with Herbmix (Hmix), animals supplemented with organic zinc (Zn) and animals supplemented with Herbmix and organic zinc (Hmix+Zn). Eggs per gram (EPG) of faeces were quantified 20, 28, 35, 42, 49, 56, 62 and 70 d post-infection and mean abomasal worm counts were assessed 70 d post-infection. Samples of blood were collected from each animal 7, 35, 49 and 70 d post-infection.
resultsQuantitative analyses of the bioactive compounds in Herbmix identified three main groups: flavonoids (9964.7 μg/g), diterpenes (4886.1 μg/g) and phenolic acids (3549.2 μg/g). Egg counts in the lambs treated with Hmix, Zn and Hmix+Zn decreased after 49 d. The EPGs in the Zn and Hmix+Zn groups were significantly lower on day 56 (P < 0.05 and P < 0.01, respectively), and the EPGs and mean worm counts were significantly lower on day 70 in all supplemented groups (P < 0.05 and P < 0.01). Hemograms of complete red blood cells of each animal identified clinical signs of haemonchosis after day 35. Serum calprotectin concentrations and IgA levels were significantly affected by treatment. The treatment influenced serum malondialdehyde concentrations (P < 0.05) and sulfhydryl groups (P < 0.01) of antioxidant status. The mineral status was unaltered in all lambs.
conclusionA direct anthelmintic impact on the viability of nematodes was not fully demonstrated, but the treatments with herbal nutraceuticals and zinc likely indirectly contributed to the increase in the resistance of the lambs to nematode infection.
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