ArticleJournal of affective disorders2018
Association between major depressive episode and risk of type 2 diabetes: A large prospective cohort study in Chinese adults.
Article in Journal of affective disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 31 citations in OpenAlex.
- Psychosomatics at the threshold: cancer, mood disorders, and the mental pain of death - where precision medicine meets spirituality.Frontiers in psychiatry · 2026Article
- Associations between depression and risk of cardiometabolic multimorbidity among middle-aged and older Chinese adults.Scientific reports · 2025Article
- First-Degree Family History of Diabetes Is Associated With the Presence of Depressive Symptoms Independent of Lifestyle Risk Factors and Cardiometabolic Risk Factors.Journal of diabetes · 2025Article
- Association of HbA1c/HDL-C ratio and depression with cardiometabolic multimorbidity in middle-aged and older adults: a nationwide prospective cohort study.Frontiers in nutrition · 2025Article
- An analysis of risk factors for spontaneously occurring type 2 diabetes mellitus in rhesus macaques (Macaca mulatta).Journal of medical primatology · 2024Article
- Serum melatonin levels in type 2 diabetic patients with depressive symptoms compared to non-depressed individuals.Caspian journal of internal medicine · 2024Article
- Higher IL-6 and IL-4 plasma levels in depressed elderly women are influenced by diabetes mellitus.Trends in psychiatry and psychotherapy · 2024Article
- The multimorbidity association of metabolic syndrome and depression on type 2 diabetes: a general population cohort study in Southwest China.Frontiers in endocrinology · 2024Article
- Association between depression and risk of type 2 diabetes and its sociodemographic factors modifications: A prospective cohort study in southwest China.Journal of diabetes · 2023Article
- PHQ-9, CES-D, health insurance data-who is identified with depression? A Population-based study in persons with diabetes.Diabetology & metabolic syndrome · 2023Article
- Exploring changes in depression and radiology-related publications research focus: A bibliometrics and content analysis based on natural language processing.Frontiers in psychiatry · 2022Article
- Comorbidity of Type 2 Diabetes Mellitus and Depression: Clinical Evidence and Rationale for the Exacerbation of Cardiovascular Disease.Frontiers in cardiovascular medicine · 2022Review
- Role of depressive symptoms in cardiometabolic diseases and subsequent transitions to all-cause mortality: an application of multistate models in a prospective cohort study.Stroke and vascular neurology · 2021Article
- Number of children and the prevalence of later-life major depression and insomnia in women and men: findings from a cross-sectional study of 0.5 million Chinese adults.BMC psychiatry · 2020Article
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13 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveWe aimed to prospectively evaluate the association between major depressive episode (MDE) and risk of type 2 diabetes in a Chinese population.
methodsWe used data from the China Kadoorie Biobank study, in which 461,213 participants free of diabetes, coronary heart disease, stroke, and cancer were followed from baseline (2004-2008) to December 31, 2013. A modified Chinese version of Composite International Diagnostic Interview Short-Form (CIDI-SF) was used to assess past year MDE. Participants who responded positive to depression screening questions but did not meet the diagnosis criteria were considered as having depressive symptoms only. Incident diabetes cases were identified through linkage with established regional disease registries and national health insurance databases. Cox proportional hazards regression model was used to calculate hazard ratio (HR) and 95% confidence interval (CI) for the association after adjusting for diabetes risk factors.
resultsWe documented 8784 incident type 2 diabetes cases during a follow-up of 3291,908 person-years. We observed a higher incidence rate of type 2 diabetes in participants with MDE than those without, and the multivariable-adjusted HR was 1.31 (95% CI 1.04-1.66). Compared with participants without depressive symptoms, the HR (95% CI) was 1.19 (1.05-1.35) for participants with depressive symptoms only and 1.32 (1.05-1.68) for those with MDE. LIMITATIONS: The prevelance of past year MDE based on CIDI-SF was low, which might result in a selection bias.
conclusionsIn our large prospective cohort study of Chinese adults, MDE was significantly and independently associated with an increased risk of type 2 diabetes.
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