Evidence map›Paper›PMID 29522833›Full record

ReviewJournal of controlled release : official journal of the Controlled Release Society2018

Ferritin-based drug delivery systems: Hybrid nanocarriers for vascular immunotargeting.

Makan Khoshnejad, Hamideh Parhiz, Vladimir V Shuvaev, Ivan J Dmochowski, Vladimir R Muzykantov

Abstract readReview
In one paragraph

Review in Journal of controlled release : official journal of the Controlled Release Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Cavity acidification limits ferritin iron biomineralization.Journal of inorganic biochemistry · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
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  11. Article
  12. Article
  13. Article
  14. Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Makan KhoshnejadDepartment of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: makank@pennmedicine.upenn.edu.
Hamideh ParhizDepartment of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Vladimir V ShuvaevDepartment of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ivan J DmochowskiDepartment of Chemistry, The School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA.
Vladimir R MuzykantovDepartment of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: muzykant@pennmedicine.upenn.edu.

Funding

Training in Molecular Therapeutics for Pediatric CardiologyT32HL007915 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Robert J Levy, JOSEPH W ROSSANO · 1999 to 2026
$13.4M
Multidisciplinary Training in Cardiovascular BiologyT32HL007954 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI DAVIES, PETER FRANCIS · 2000 to 2019
$9.9M
Targeted nanomedicine for ALI and I/RR01HL125462 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MUZYKANTOV, VLADIMIR R · 2015 to 2018
$2.3M
Targeting novel biotherapeutics to endotheliumR01HL128398 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MUZYKANTOV, VLADIMIR R · 2015 to 2018
$2.2M
Endothelial targeting of antioxidantsR01HL126874 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MUZYKANTOV, VLADIMIR R · 2016 to 2019
$1.7M
NHLBI NIH HHS R01 HL125462NHLBI NIH HHS R01 HL126874NHLBI NIH HHS R01 HL128398NHLBI NIH HHS T32 HL007915NHLBI NIH HHS T32 HL007954
6 · The paper itself

Abstract

Ferritin subunits of heavy and light polypeptide chains self-assemble into a spherical nanocage that serves as a natural transport vehicle for metals but can include diverse cargoes. Ferritin nanoparticles are characterized by remarkable stability, small and uniform size. Chemical modifications and molecular re-engineering of ferritin yield a versatile platform of nanocarriers capable of delivering a broad range of therapeutic and imaging agents. Targeting moieties conjugated to the ferritin external surface provide multivalent anchoring of biological targets. Here, we highlight some of the current work on ferritin as well as examine potential strategies that could be used to functionalize ferritin via chemical and genetic means to enable its utility in vascular drug delivery.

Indexed as

Blood VesselsDrug Delivery SystemsAnimalsAntineoplastic AgentsDrug CarriersFerritinsHumansLungModels, MolecularNanoparticlesNeoplasmsPositron-Emission TomographyVaccinesAntineoplastic AgentsDrug CarriersFerritinsVaccines

Identifiers

PMID29522833
PMCPMC6008199

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.