ArticleCellular signalling2018
Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Cellular signalling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Inositol pyrophosphate kinases in health and disease.FEBS letters · 2026Review
- Placental DNA methylation captures shared and trait-specific genetic susceptibility across complex health conditions.medRxiv : the preprint server for health sciences · 2026Article
- The inositol pyrophosphate 5-InsPThe Journal of biological chemistry · 2026Article
- Physiological roles of phosphoinositides and inositol phosphates: Implications for metabolic dysfunction-associated steatotic liver disease.Clinical science (London, England : 1979) · 2025Review
- Insights into the roles of inositol hexakisphosphate kinase 1 (IP6K1) in mammalian cellular processes.The Journal of biological chemistry · 2024Review
- Functions, Mechanisms, and therapeutic applications of the inositol pyrophosphates 5PP-InsPJournal of cardiovascular translational research · 2024Review
- Article
- 5-IPNature metabolism · 2021Article
- Article
- XPR1 Mediates the Pancreatic β-Cell Phosphate Flush.Diabetes · 2021Article
- Signalling Properties of Inositol Polyphosphates.Molecules (Basel, Switzerland) · 2020Review
- Role of Inositols and Inositol Phosphates in Energy Metabolism.Molecules (Basel, Switzerland) · 2020Review
- Metabolism and Functions of Inositol Pyrophosphates: Insights Gained from the Application of Synthetic Analogues.Molecules (Basel, Switzerland) · 2020Review
- The inositol pyrophosphate 5-InsPScience advances · 2020Article
- The Key Role of IPMolecules (Basel, Switzerland) · 2020Review
- InsPProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals.Molecules (Basel, Switzerland) · 2020Review
- A two-way switch for inositol pyrophosphate signaling: Evolutionary history and biological significance of a unique, bifunctional kinase/phosphatase.Advances in biological regulation · 2020Review
- Inositol hexakisphosphate kinase 3 promotes focal adhesion turnover via interactions with dynein intermediate chain 2.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors at 5 institutions in 4 countries.
Subu Surendran RajasekaranThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
Jaeyoon KimThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden; School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea.
Gian-Carlo GaboardiThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
Jesper GromadaRegeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
Stephen B ShearsSignal Transduction Laboratory/Inositol Signaling Group, NIEHS, Building 101, Room F239,111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA.
Karen Tiago Dos SantosThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden; Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Eduardo Lima NolascoThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden; Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Sabrina de Souza FerreiraThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden; Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Christopher IlliesThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
Martin KöhlerThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
Chunfang GuSignal Transduction Laboratory/Inositol Signaling Group, NIEHS, Building 101, Room F239,111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA.
Sung Ho RyuDepartment of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea.
Joilson O MartinsLaboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Elisabetta DarèThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
Christopher J BarkerThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden. Electronic address: chris.barker@ki.se.
Per-Olof BerggrenThe Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden; School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea. Electronic address: per-olof.berggren@ki.se.
Karolinska Institutet · SEUniversidade de São Paulo · BRNational Institute of Environmental Health Sciences · USPohang University of Science and Technology · KRRegeneron (United States) · US
Funding
Inositol SignallingZIAES080046 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SHEARS, STEPHEN B · 2009 to 2023
$31.3MAbstract
Diphosphoinositol pentakisphosphate (IP
Indexed as
Adenosine DiphosphateAdenosine TriphosphateAnimalsDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Gene Knockdown TechniquesGlucoseHumansInositol PhosphatesInsulin-Secreting CellsInsulin SecretionMiceMice, Inbred C57BLPhosphotransferases (Phosphate Group Acceptor)1-diphosphoinositol pentakisphosphateAdenosine DiphosphateAdenosine TriphosphateGlucoseIhpk1 protein, mouseInositol PhosphatesIP6K1 protein, humanPhosphotransferases (Phosphate Group Acceptor)ATP/ADPDiphosphoinositol pentakisphosphate/ IP(7)Inositol hexakisphosphate kinase 1Insulin secretionPancreatic beta cellType 2 diabetes
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.