Evidence map›Paper›PMID 29522805›Full record

ArticleMethods (San Diego, Calif.)2018

Nonuniform sampling in multidimensional NMR for improving spectral sensitivity.

Matthew A Zambrello, Adam D Schuyler, Mark W Maciejewski, Frank Delaglio, Irina Bezsonova, Jeffrey C Hoch

Abstract read
In one paragraph

Article in Methods (San Diego, Calif.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matthew A ZambrelloUConn Health, Department of Molecular Biology and Biophysics, 263 Farmington Avenue, Farmington, CT 06030-3305, USA.
Adam D SchuylerUConn Health, Department of Molecular Biology and Biophysics, 263 Farmington Avenue, Farmington, CT 06030-3305, USA.
Mark W MaciejewskiUConn Health, Department of Molecular Biology and Biophysics, 263 Farmington Avenue, Farmington, CT 06030-3305, USA.
Frank DelaglioInstitute for Bioscience and Biotechnology Research, National Institute of Standards and Technology and the University of Maryland, 9600 Gudelsky Drive, Rockville, MD 20850, USA.
Irina BezsonovaUConn Health, Department of Molecular Biology and Biophysics, 263 Farmington Avenue, Farmington, CT 06030-3305, USA.
Jeffrey C HochUConn Health, Department of Molecular Biology and Biophysics, 263 Farmington Avenue, Farmington, CT 06030-3305, USA. Electronic address: hoch@uchc.edu.

Funding

TRD3 NMRbox: Bayesian AnalyticsP41GM111135 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HOCH, JEFFREY C · 2015 to 2024
$14.0M
Development and Application of Non-Fourier Method for Biomolecular NMRR01GM123249 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HOCH, JEFFREY C · 2018 to 2021
$1.5M
Novel Computational Techniques to Expand the Scope of Protein Nuclear Magnetic Resonance SpectroscopyF30DE026353 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI ZAMBRELLO, MATTHEW · 2016 to 2019
$178k
Intramural NIST DOC 9999-NISTNIDCR NIH HHS F30 DE026353NIGMS NIH HHS P41 GM111135NIGMS NIH HHS R01 GM123249
6 · The paper itself

Abstract

The development of multidimensional NMR spectroscopy enabled an explosion of structural and dynamical investigations on proteins and other biomacromolecules. Practical limitations on data sampling, based on the Jeener paradigm of parametric sampling of indirect time domains, have long placed limits on resolution in the corresponding frequency dimensions. The emergence of nonuniform sampling (NUS) in indirect time dimensions circumvents those limitations, affording high resolution spectra from short data records collected in practically realized measurement times. In addition to substantially improved resolution, NUS can also be exploited to improve sensitivity, with gains comparable to those obtained using cryogenically cooled probes. We describe a general approach for acquiring and processing multidimensional NUS NMR data for improving sensitivity.

Indexed as

Protein ConformationMagnetic Resonance SpectroscopyMolecular StructureSensitivity and Specificity

Identifiers

PMID29522805
PMCPMC5984134

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.