Evidence map›Paper›PMID 29522717›Full record

ArticleBiochemical and biophysical research communications2018

Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants.

Amy L Patton, Kathryn A Seely, Azure L Yarbrough, William Fantegrossi, Laura P James, Keith R McCain, Ryoichi Fujiwara, Paul L Prather, Jeffery H Moran, Anna Radominska-Pandya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Synthetic Cannabinoid-Related Deaths in England, 2012-2019.Cannabis and cannabinoid research · 2022
    Article
  4. Review
  5. The Spicy Story of Cannabimimetic Indoles.Molecules (Basel, Switzerland) · 2021
    Review
  6. Article
  7. Article
  8. Synthetic Cannabinoid Hydroxypentyl Metabolites Retain Efficacy at Human Cannabinoid Receptors.The Journal of pharmacology and experimental therapeutics · 2019
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Amy L PattonArkansas Department of Health, Arkansas Public Health Laboratory, 4815 W Markham St, Little Rock, AR, 72205, USA; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR, 72205, USA. Electronic address: amy.patton@pinpointtesting.com.
Kathryn A SeelyArkansas Department of Health, Arkansas Public Health Laboratory, 4815 W Markham St, Little Rock, AR, 72205, USA. Electronic address: Katie.Seely@arkansas.gov.
Azure L YarbroughDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR, 72205, USA. Electronic address: ALYarbrough@uams.edu.
William FantegrossiDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR, 72205, USA. Electronic address: WEFantegrossi@uams.edu.
Laura P JamesDepartment of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, 4301 W Markham St #550, Little Rock, AR, 72205, USA. Electronic address: JamesLauraP@uams.edu.
Keith R McCainDepartment of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, 4301 W Markham St #550, Little Rock, AR, 72205, USA. Electronic address: MccainKeith@uams.edu.
Ryoichi FujiwaraDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR, 72205, USA. Electronic address: rfujiwara@uams.edu.
Paul L PratherDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR, 72205, USA. Electronic address: pratherpaull@uams.edu.
Jeffery H MoranArkansas Department of Health, Arkansas Public Health Laboratory, 4815 W Markham St, Little Rock, AR, 72205, USA. Electronic address: jeff.moran@pinpointtesting.com.
Anna Radominska-PandyaDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR, 72205, USA. Electronic address: radominskaanna@uams.edu.
University of Arkansas for Medical Sciences · USArkansas Department of Health · US

Funding

Synthetic Cannabinoid Toxicity: Role of BiotransformationR01DA039143 · NIDA · UNIV OF ARKANSAS FOR MED SCIS · PI PRATHER, PAUL L · 2016 to 2020
$2.9M
NIDA NIH HHS R01 DA039143
6 · The paper itself

Abstract

Synthetic cannabinoids (SCBs), synonymous with 'K2', 'Spice' or 'synthetic marijuana', are psychoactive drugs of abuse that frequently result in clinical effects and toxicity more severe than those classically associated with Δ

Indexed as

Cytochrome P-450 CYP2C9HumansIllicit DrugsIndolesKineticsMetabolic Networks and PathwaysNaphthalenesOxidation-ReductionPolymorphism, GeneticRecombinant ProteinsSubstance-Related Disorders1-pentyl-3-(1-naphthoyl)indoleCYP2C9 protein, humanCytochrome P-450 CYP2C9Illicit DrugsIndolesNaphthalenesRecombinant ProteinsCYP2C9 variantsCYP450Enzyme kineticsSynthetic cannabinoidsToxicity

Identifiers

PMID29522717
PMCPMC6425723
OpenAlexW2793537300

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.