ArticlePloS one2018
Women with adenomyosis are at higher risks of endometrial and thyroid cancers: A population-based historical cohort study.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- The association between endometriosis and risk of endometrial cancer and breast cancer: a meta-analysis.BMC women's health · 2022Pooled it
- Endometrial carcinoma risk prediction and gynecological comorbidity in adenomyosis: a 5648-case study.BMC women's health · 2026Article
- Coexistence of gynecological pathology with endometriosis and adenomyosis.Molecular and clinical oncology · 2026Article
- Association between adenomyosis subtypes and concurrent endometrial lesions: a propensity score-matched retrospective study.Frontiers in endocrinology · 2026Article
- Maternal and Neonatal Outcomes in Pregnancies with Adenomyosis.Maternal and child health journal · 2025Article
- Flavone-based dual PARP-Tubulin inhibitor manifesting efficacy against endometrial cancer.Journal of enzyme inhibition and medicinal chemistry · 2023Article
- Endometrial cell‑derived exosomes facilitate the development of adenomyosis via the IL‑6/JAK2/STAT3 pathway.Experimental and therapeutic medicine · 2023Article
- Female Papillary Thyroid Cancer Survivors Are at Increased Risk of Adenomyosis and Endometrial Hyperplasia.Cureus · 2023Article
- Applying contrast-enhanced ultrasound model to distinguish atypical focal adenomyosis from uterine leiomyomas.Annals of translational medicine · 2022Article
- Article
- Maternal-Fetal Outcomes in Women with Endometriosis and Shared Pathogenic Mechanisms.Medicina (Kaunas, Lithuania) · 2021Review
- Origin and Pathogenic Mechanisms of Uterine Adenomyosis: What Is Known So Far.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- WNK1 regulates uterine homeostasis and its ability to support pregnancy.JCI insight · 2020Article
- Human immunodeficiency: Extragonadal comorbidities of infertility in women.Immunity, inflammation and disease · 2020Review
- Epidemiology of Adenomyosis.Seminars in reproductive medicine · 2020Review
- The clinicopathological characteristics and survival outcomes of endometrial carcinoma coexisting with or arising in adenomyosis: A pilot study.Scientific reports · 2020Article
- Co-existence of leiomyomas, adenomyosis and endometriosis in women with endometrial cancer.Scientific reports · 2020Article
- Association of benign gynaecological diseases and risk of endometrial and ovarian cancers.Journal of Cancer · 2020Article
- mFrontiers in genetics · 2020Article
- Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBoth adenomyosis and endometriosis are characterized by the presence of ectopic endometrial glands and stroma and have been suggested to share some characteristics with malignant tumors. Although accumulating evidence indicates that endometriosis is associated with some cancer types, the cancer risks in patients with adenomyosis have been rarely examined. In this study, we investigated the relationship between adenomyosis and risks of common cancers.
methodsThis study included a cohort of 12,447 women with adenomyosis but not endometriosis, born in 1951-1984, and a cohort of 124,470 adenomyosis-free women matched by birth year. Their medical records (collected between 1996 and 2011) were obtained from the National Health Insurance Research Database of Taiwan. We first compared the distribution of cancer-free survival (CFS) between cohorts with and without adenomyosis. Subsequently, within the adenomyosis cohort, we examined whether time-to-onset of the identified cancer type was correlated with time-to-onset of adenomyosis. The Cox proportional hazards model was used to compare the distribution of CFS between the adenomyosis and adenomyosis-free cohorts and between the early- and late-diagnosed adenomyosis groups. For comparison, we further evaluated the cancer risks for a cohort of 10,962 women with endometriosis but not adenomyosis and a birth-year matched cohort of 109,620 endometriosis-free women.
resultsCompared with adenomyosis-free women, patients with adenomyosis had higher risks of endometrial and thyroid cancers, with estimated hazard ratios (HRs) (95% confidence interval) of 2.19 (1.51-3.16) and 1.70 (1.29-2.24), respectively. For both cancers, distributions of CFS were not significantly different between the early- and late-diagnosed adenomyosis groups. Furthermore, compared with endometriosis-free women, patients with endometriosis had higher risks of endometrial and ovarian cancers, with HRs of 1.89 (1.07-3.35) and 2.01 (1.27-3.16), respectively.
conclusionsWomen with adenomyosis are at higher risks of endometrial and thyroid cancers, while women with endometriosis are at higher risks of endometrial and ovarian cancers.
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