ArticlePLoS neglected tropical diseases2018
Quantitative evaluation of maxillary bone deformation by computed tomography in patients with leprosy.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 12 citations in OpenAlex.
- Lepromatous leprosy in Bronze Age Oman: micro-CT provides tools for paleopathology in fragmentary and commingled assemblages.Frontiers in medicine · 2025Article
- Clinical and radiological evaluation of maxillofacial and otorhinolaryngological manifestations of Hansen's disease.Scientific reports · 2022Article
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- Evaluation of proposed cranial and maxillary bone alteration parameters in persons affected by Hansen's disease.PLoS neglected tropical diseases · 2021Article
- Objective computerised assessment of residual ridge resorption in the human maxilla and maxillary sinus pneumatisation.Clinical oral investigations · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
backgroundFacial deformation as a sequela of leprosy is caused not only by a saddle nose but also by regression of the maxilla, as well documented in paleopathological observations of excavated skeletal remains of patients with leprosy. However, maxillary changes in living patients have been evaluated only by the subjective visual grading. Here, we attempted to evaluate maxillary bone deformation in patients with leprosy using three-dimensional computed tomography (3D-CT).
methodsThree-dimensional images centered on the maxilla were reconstructed using multiplanar reconstruction methods in former patients with leprosy (n = 10) and control subjects (n = 5); the anterior-posterior length of the maxilla (MA-P) was then measured. The difference between the MA-P of the patients and those of controls was evaluated after compensating for individual skull size. These findings were also compared with those from previous paleopathological studies.
findingsThree former patients with lepromatous leprosy showed marked atrophy of the maxilla at the prosthion (-8.6, -11.1 and -17.9 mm) which corresponded with the visual appearance of the maxillary deformity, and these results were consistent with paleopathological findings of excavated skeletal remains. Additionally, the precise bone defects of the maxilla could be individually calculated for accurate reconstructive surgery.
interpretationWe have successfully illustrated maxillary bone deformities in living patients with leprosy. This study also confirmed the maxillary regression described in paleopathological studies.
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