Evidence map›Paper›PMID 29522497›Full record

ReviewBioengineering (Basel, Switzerland)2018

Stem Cells and Engineered Scaffolds for Regenerative Wound Healing.

Biraja C Dash, Zhenzhen Xu, Lawrence Lin, Andrew Koo, Sifon Ndon, Francois Berthiaume, Alan Dardik, Henry Hsia

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed.

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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Biraja C DashDepartment of Surgery (Plastic), Yale School of Medicine, New Haven, CT 06510, USA. biraja.dash@yale.edu.ORCID 0000-0002-1795-3284
Zhenzhen XuDepartment of Surgery (Plastic), Yale School of Medicine, New Haven, CT 06510, USA. zhenzhen.xu@yale.edu.
Lawrence LinDepartment of Public Health Studies, Johns Hopkins University, Baltimore, MD 21218, USA. llin31@jhu.edu.
Andrew KooDepartment of Surgery (Plastic), Yale School of Medicine, New Haven, CT 06510, USA. andrew.koo@yale.edu.
Sifon NdonDepartment of Surgery (Plastic), Yale School of Medicine, New Haven, CT 06510, USA. sifon.ndon@yale.edu.
Francois BerthiaumeDepartment of Biomedical Engineering, Rutgers University, The State University New Jersey, Piscataway, NJ 08901, USA. fberthia@soe.rutgers.edu.
Alan DardikDepartment of Surgery (Vascular), Yale School of Medicine, New Haven, CT 06510, USA. alan.dardik@yale.edu.
Henry HsiaDepartment of Surgery (Plastic), Yale School of Medicine, New Haven, CT 06510, USA. henry.hsia@yale.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Multifunctional Nanoparticles Containing sRAGE Potentiated Bioactive Peptides for Wound HealingR21EB021570 · NIBIB · RUTGERS, THE STATE UNIV OF N.J. · PI BERTHIAUME, FRANCOIS, YARMUSH, MARTIN L · 2016 to 2017
$442k
NCATS NIH HHS UL1 TR001863NIBIB NIH HHS R21 EB021570
6 · The paper itself

Abstract

The normal wound healing process involves a well-organized cascade of biological pathways and any failure in this process leads to wounds becoming chronic. Non-healing wounds are a burden on healthcare systems and set to increase with aging population and growing incidences of obesity and diabetes. Stem cell-based therapies have the potential to heal chronic wounds but have so far seen little success in the clinic. Current research has been focused on using polymeric biomaterial systems that can act as a niche for these stem cells to improve their survival and paracrine activity that would eventually promote wound healing. Furthermore, different modification strategies have been developed to improve stem cell survival and differentiation, ultimately promoting regenerative wound healing. This review focuses on advanced polymeric scaffolds that have been used to deliver stem cells and have been tested for their efficiency in preclinical animal models of wounds.

Indexed as

chronic woundnatural polymerscaffoldstem cellsurface modificationsynthetic polymer

Identifiers

PMID29522497
PMCPMC5874889

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.