Evidence map›Paper›PMID 29522375›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2018

Fropofol decreases force development in cardiac muscle.

Xianfeng Ren, William Schmidt, Yiyuan Huang, Haisong Lu, Wenjie Liu, Weiming Bu, Roderic Eckenhoff, Anthony Cammarato, Wei Dong Gao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Human Resistin Induces Cardiac Dysfunction in Pulmonary Hypertension.Journal of the American Heart Association · 2023
    Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Xianfeng RenDepartment of Anesthesiology, China-Japan Friendship Hospital, Beijing, China.
William SchmidtDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yiyuan HuangDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Haisong LuDepartment of Anesthesiology, Fuwai Hospital, Beijing, China.
Wenjie LiuDepartment of Anesthesiology, South China University School of Medicine, China.
Weiming BuDepartment of Anesthesiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Roderic EckenhoffDepartment of Anesthesiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Anthony CammaratoDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Wei Dong GaoDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Johns Hopkins University · USUniversity of Pennsylvania · USChina-Japan Friendship Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNJohns Hopkins Medicine · USSouth China University of Technology · CN

Funding

PATHOPHYSIOLOGY OF MYOCARDIAL DISEASEST32HL007227 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chulan Kwon, WENDY S POST · 1985 to 2026
$21.2M
PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM008076 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BLENDY, JULIE A · 1985 to 2023
$10.8M
PATHOGENESIS AND IN VIVO SUPPRESSION OF THIN FILAMENT-BASED CARDIOMYOPATHIESR01HL124091 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Anthony Cammarato · 2015 to 2026
$4.3M
DUAL ROLE FOR CDC13 IN YEAST TELOMERE FUNCTIONR01GM055867 · NIGMS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI LUNDBLAD, VICTORIA · 1997 to 2004
$1.4M
Light-enabled identification of the neural substrates for alkylphenol anesthesiaF31NS080519 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI WEISER, BRIAN PATRICK · 2012 to 2014
$108k
NHLBI NIH HHS R01 HL124091NHLBI NIH HHS T32 HL007227NIGMS NIH HHS R01 GM055867NIGMS NIH HHS T32 GM008076NINDS NIH HHS F31 NS080519
6 · The paper itself

Abstract

Supranormal contractile properties are frequently associated with cardiac diseases. Anesthetic agents, including propofol, can depress myocardial contraction. We tested the hypothesis that fropofol, a propofol derivative, reduces force development in cardiac muscles via inhibition of cross-bridge cycling and may therefore have therapeutic potential. Force and intracellular Ca

Indexed as

ActinsActomyosinAdenosine TriphosphatasesAnestheticsAnimalsCalciumHeartMuscle ContractionMyocardial ContractionMyocardiumMyosinsPropofolRatsActinsActomyosinAdenosine TriphosphatasesAnestheticsCalciumMyosinsPropofolexcitation contraction couplingfropofolintracellular calciumin vitro motilitymyofilament protein

Identifiers

PMID29522375
PMCPMC6044060
OpenAlexW2792860675

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.