ArticleAmerican journal of respiratory cell and molecular biology2018
Early Endotyping: A Chance for Intervention in Chronic Obstructive Pulmonary Disease.
Article in American journal of respiratory cell and molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Endotyping COPD: hypoxia-inducible factor-2 as a molecular "switch" between the vascular and airway phenotypes?European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Wood smoke exposure affects lung aging, quality of life, and all-cause mortality in New Mexican smokers.Respiratory research · 2022Article
- Inflammatory response in human lung cells stimulated with plasma from COPD patients.Multidisciplinary respiratory medicine · 2022Article
- Effect Analysis of Lung Rehabilitation Training in 5A Nursing Mode for Elderly Patients with COPD Based on X-Ray.Computational and mathematical methods in medicine · 2022Article
- CD19 and POU2AF1 are Potential Immune-Related Biomarkers Involved in the Emphysema of COPD: On Multiple Microarray Analysis.Journal of inflammation research · 2022Article
- Individual trajectory-based care for COPD: getting closer, but not there yet.ERJ open research · 2021Review
- Functional Gene Variants in Chronic Obstructive Pulmonary Disease: The Search Continues.American journal of respiratory cell and molecular biology · 2021Article
- Chronic exposure to diesel exhaust may cause small airway wall thickening without lumen narrowing: a quantitative computerized tomography study in Chinese diesel engine testers.Particle and fibre toxicology · 2021Article
- How might endotyping guide chronic obstructive pulmonary disease treatment? Current understanding, knowledge gaps and future research needs.Current opinion in pulmonary medicine · 2021Review
- Small Airway Wall Thickening Assessed by Computerized Tomography Is Associated With Low Lung Function in Chinese Carbon Black Packers.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- B Cell-Adaptive Immune Profile in Emphysema-Predominant Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2019Article
- COPD: To Be or Not to Be, That is the Question.The American journal of medicine · 2019Review
- Chronic Obstructive Pulmonary Disease and the Optimal Timing of Lung Transplantation.Medicina (Kaunas, Lithuania) · 2019Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Chronic obstructive pulmonary disease (COPD) is a syndrome that comprises several lung pathologies, but subphenotyping the various disease subtypes has been difficult. One reason may be that current efforts focused on studying COPD once it has occurred do not allow tracing back to the different origins of disease. This perspective proposes that emphysema originates when susceptible airway, endothelial, and/or hematopoietic cells are exposed to environmental toxins such as cigarette smoke, biomass fuel, or traffic emissions. These susceptible cell types may initiate distinct pathobiological mechanisms ("COPD endotypes") that ultimately manifest the emphysematous destruction of the lung. On the basis of evidence from the "airway" endotype, we suggest that grading these endotypes by severity may allow better diagnosis of disease at early stages when intervention can be designed on the basis of the mechanisms involved. Therefore, genomic, proteomic, and metabolomic studies on at-risk patients will be important in the identification of biomarkers that help designate each endotype. Together with understanding of the involved molecular pathways that lead to disease manifestation, these efforts may lead to development of intervention strategies.
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