SynthesisClinical infectious diseases : an official publication of the Infectious Diseases Society of America2018
Case Fatality Rate of Enteric Fever in Endemic Countries: A Systematic Review and Meta-analysis.
Synthesis in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Enteric Fever-Associated Hemophagocytic Lymphohistiocytosis: A Systematic Review of Clinical Characteristics and Outcomes.The American journal of tropical medicine and hygiene · 2024Pooled it
- Estimating case fatality risk of severe Yellow Fever cases: systematic literature review and meta-analysis.BMC infectious diseases · 2021Pooled it
- Etiological spectrum of persistent fever in the tropics and predictors of ubiquitous infections: a prospective four-country study with pooled analysis.BMC medicine · 2022Trial
- Effective strategies for typhoid conjugate vaccine delivery: Health and economic insights from the 2015 Kampala outbreak.PLoS neglected tropical diseases · 2025Article
- TheVaccines · 2025Article
- The global burden of enteric fever, 2017-2021: a systematic analysis from the global burden of disease study 2021.EClinicalMedicine · 2024Article
- Article
- A phase II clinical trial of a Vi-DT typhoid conjugate vaccine in healthy Indonesian adolescents and adults: one-month evaluation of safety and immunogenicity.Tropical diseases, travel medicine and vaccines · 2024Article
- Article
- What Should We Be Recommending for the Treatment of Enteric Fever?Open forum infectious diseases · 2023Article
- Cost-effectiveness analysis of typhoid conjugate vaccines in an outbreak setting: a modeling study.BMC infectious diseases · 2023Article
- Quantitative bacterial counts in the bone marrow of Vietnamese patients with typhoid fever.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2022Article
- The Burden of Typhoid Fever in Sub-Saharan Africa: A Perspective.Research and reports in tropical medicine · 2022Review
- Clinical spectrum and outcomes of patients with different resistance patterns ofPakistan journal of medical sciences · 2022Article
- Burden of enteric fever at three urban sites in Africa and Asia: a multicentre population-based study.The Lancet. Global health · 2021Article
- Case-Fatality Ratio of Enteric Fever: Estimates From Multitiered Surveillance in India.The Journal of infectious diseases · 2021Article
- Enteric Fever: Diagnostic Dilemma Encountered in Domperidone-Induced Neuroleptic Malignant Syndrome.Cureus · 2021Article
- Enteric fever.BMJ (Clinical research ed.) · 2021Article
- Illness Severity and Outcomes Among Enteric Fever Cases From Bangladesh, Nepal, and Pakistan: Data From the Surveillance for Enteric Fever in Asia Project, 2016-2019.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Generation and Characterization of Typhoid Toxin-Neutralizing Human Monoclonal Antibodies.Infection and immunity · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enteric fever is a febrile illness, occurring mostly in Asia and Africa, which can present as a severe and possibly fatal disease. Currently, a case fatality rate (CFR) of 1% is assumed when evaluating the global burden of enteric fever. Until now, no meta-analysis has been conducted to summarize mortality from enteric fever. Therefore, we conducted a systematic review and meta-analysis to aggregate all available evidence. We estimated an overall CFR of 2.49% (95% confidence interval, 1.65%-3.75%; n = 44), and a CFR in hospitalized patients of 4.45% (2.85%-6.88%; n = 21 of 44). There was considerably heterogeneity in estimates of the CFR from individual studies. Neither age nor antimicrobial resistance were significant prognostic factors, but limited data were available for these analyses. The combined estimate of the CFR for enteric fever is higher than previously estimated, and the evaluation of prognostic factors, including antimicrobial resistance, urgently requires more data.
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