Evidence map›Paper›PMID 29521627›Full record

ArticleeLife2018

A compartmentalized signaling network mediates crossover control in meiosis.

Liangyu Zhang, Simone Köhler, Regina Rillo-Bohn, Abby F Dernburg

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 113 citations in OpenAlex.

  1. Article
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  6. Structure and function of the synaptonemal complex.The Journal of cell biology · 2026
    Review
  7. High-resolution global recombination mapping inbioRxiv : the preprint server for biology · 2026
    Article
  8. Article
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  10. Review
  11. Article
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  15. Article
  16. Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. Review

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Liangyu ZhangDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID http://orcid.org/0000-0002-2701-0773
Simone KöhlerDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.
Regina Rillo-BohnDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.
Abby F DernburgDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID http://orcid.org/0000-0001-8037-1079
QB3 · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Crossover control during meiosisR01GM065591 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI DERNBURG, ABBY F · 2002 to 2021
$4.5M
Genome Sequencer FLXS10RR029668 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI NGAI, JOHN J. · 2010 to 2010
$623k
Illumina Sequencer to Facilitate Functional Genomics at BerkeleyS10RR027303 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI TAYLOR, JOHN W. · 2010 to 2010
$500k
Howard Hughes Medical InstituteNCRR NIH HHS S10 RR027303NCRR NIH HHS S10 RR029668NIGMS NIH HHS GM065591NIGMS NIH HHS R01 GM065591NIH HHS P40 OD010440
6 · The paper itself

Abstract

During meiosis, each pair of homologous chromosomes typically undergoes at least one crossover (crossover assurance), but these exchanges are strictly limited in number and widely spaced along chromosomes (crossover interference). The molecular basis for this chromosome-wide regulation remains mysterious. A family of meiotic RING finger proteins has been implicated in crossover regulation across eukaryotes.

Indexed as

AnimalsCaenorhabditis elegansCell CompartmentationChromosome SegregationCrossing Over, GeneticMeiosisSignal TransductionSynaptonemal ComplexC. eleganscell biologychromosomescrossover controlgene expressionhomologous recombinationmeiosisRING finger ligasesynaptonemal ComplexTuring pattern

Identifiers

PMID29521627
PMCPMC5906097
OpenAlexW2793260763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.