Evidence map›Paper›PMID 29521625›Full record

ArticleeLife2018

CRISPR-based herd immunity can limit phage epidemics in bacterial populations.

Pavel Payne, Lukas Geyrhofer, Nicholas H Barton, Jonathan P Bollback

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 40 citations in OpenAlex.

  1. Temperate phages limit their own propagation under spatial constraint in biofilms on chitin.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  5. Abiotic environmental conditions determine phage resistance outcomes in a salt-marsh bacterium.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
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  6. Article
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  12. Protection of bacteriophage-sensitiveProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  13. Article
  14. On Phage Adsorption to Bacterial Chains.Biophysical journal · 2020
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Diversified local CRISPR-Cas immunity to viruses of Sulfolobus islandicus.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Pavel PayneInstitute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom.ORCID http://orcid.org/0000-0002-2711-9453
Lukas GeyrhoferDepartment of Chemical Engineering, Technion - Israel Institute of Technology, Haifa, Israel.ORCID http://orcid.org/0000-0002-8043-2975
Nicholas H BartonInstitute of Science and Technology Austria, Klosterneuburg, Austria.
Jonathan P BollbackInstitute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom.ORCID https://orcid.org/0000-0002-4624-4612
University of Liverpool · GBInstitute of Science and Technology Austria · ATTechnion – Israel Institute of Technology · IL

Funding

European Research Council EVOLHGT No. 648440
6 · The paper itself

Abstract

Herd immunity, a process in which resistant individuals limit the spread of a pathogen among susceptible hosts has been extensively studied in eukaryotes. Even though bacteria have evolved multiple immune systems against their phage pathogens, herd immunity in bacteria remains unexplored. Here we experimentally demonstrate that herd immunity arises during phage epidemics in structured and unstructured

Indexed as

Evolution, MolecularModels, TheoreticalAnimalsBacteriaBacteriophagesEpidemicsEscherichia coliEukaryotaHumansImmunity, HerdbacteriaCRISPRE. coliecologyepidemicevolutionary biologygenomicsherd immunityphagepolymorphism

Identifiers

PMID29521625
PMCPMC5922976
OpenAlexW2951026085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.