ArticleEnvironmental microbiology2018
A horizontally gene transferred copper resistance locus confers hyper-resistance to antibacterial copper toxicity and enables survival of community acquired methicillin resistant Staphylococcus aureus USA300 in macrophages.
Article in Environmental microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 57 citations in OpenAlex.
- Genomic diversity and resistance determinants of staphylococci from cow and buffalo milk.Molecular biology reports · 2026Article
- Copper Metabolism in Isolated Macrophages: Regulator of Immunity and Inflammation.Veterinary sciences · 2026Review
- Review
- From Fungicide to Phagosome: A One Health View of Copper-Driven Fungal-Bacterial Interactions.Current clinical microbiology reports · 2026Review
- Bacterial Metallostasis: Metal Sensing, Metalloproteome Remodeling, and Metal Trafficking.Chemical reviews · 2024Review
- Cross-regulation and cross-talk of conserved and accessory two-component regulatory systems orchestrate Pseudomonas copper resistance.PLoS genetics · 2024Article
- Copper management strategies in obligate bacterial symbionts: balancing cost and benefit.Emerging topics in life sciences · 2024Article
- Virulence attributes of successful methicillin-resistantClinical microbiology reviews · 2023Review
- Copper ions inhibit pentose phosphate pathway function in Staphylococcus aureus.PLoS pathogens · 2023Article
- Mutations inApplied and environmental microbiology · 2023Article
- Copper microenvironments in the human body define patterns of copper adaptation in pathogenic bacteria.PLoS pathogens · 2022Review
- Role of horizontally transferred copper resistance genes inMicrobiology (Reading, England) · 2022Review
- Contribution of Arginine Catabolic Mobile Element and Copper and Mercury Resistance Element in Methicillin-ResistantThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022Review
- Article
- Whole Genome Sequencing of Methicillin-ResistantMicroorganisms · 2021Article
- Staphylococcus aureus lacking a functional MntABC manganese import system has increased resistance to copper.Molecular microbiology · 2021Article
- Review
- Comparative Genomics Analysis Demonstrated a Link Between Staphylococci Isolated From Different Sources: A Possible Public Health Risk.Frontiers in microbiology · 2021Article
- Genetic Regulation of Metal Ion Homeostasis in Staphylococcus aureus.Trends in microbiology · 2020Review
- Additive effects of metal excess and superoxide, a highly toxic mixture in bacteria.Microbial biotechnology · 2020Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
Excess copper is highly toxic and forms part of the host innate immune system's antibacterial arsenal, accumulating at sites of infection and acting within macrophages to kill engulfed pathogens. We show for the first time that a novel, horizontally gene transferred copper resistance locus (copXL), uniquely associated with the SCCmec elements of the highly virulent, epidemic, community acquired methicillin resistant Staphylococcus aureus (CA-MRSA) USA300, confers copper hyper-resistance. These genes are additional to existing core genome copper resistance mechanisms, and are not found in typical S. aureus lineages, but are increasingly identified in emerging pathogenic isolates. Our data show that CopX, a putative P
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.