Evidence map›Paper›PMID 29521335›Full record

ReviewNature reviews. Neurology2018

Nontraumatic intracerebral haemorrhage in young adults.

Turgut Tatlisumak, Brett Cucchiara, Satoshi Kuroda, Scott E Kasner, Jukka Putaala

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Pediatric hemorrhagic stroke in southern China: Analysis of 159 cases.The Journal of international medical research · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Article
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  13. Article
  14. Article
  15. Review
  16. Article
  17. Vasculitis and cerebral hemorrhage due toSAGE open medical case reports · 2024
    Article
  18. Article
  19. Intracerebral haemorrhage.Nature reviews. Disease primers · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 4 countries.

Turgut TatlisumakDepartment of Clinical Neuroscience and Neurology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.
Brett CucchiaraComprehensive Stroke Center, Department of Neurology, University of Pennsylvania and University of Pennsylvania Medical Center, Philadelphia, PA, USA.
Satoshi KurodaDepartment of Neurosurgery, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama Prefecture, Japan.
Scott E KasnerComprehensive Stroke Center, Department of Neurology, University of Pennsylvania and University of Pennsylvania Medical Center, Philadelphia, PA, USA.
Jukka PutaalaDepartment of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
University of Pennsylvania · USHelsinki University Hospital · FISahlgrenska University Hospital · SEUniversity of Toyama · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nontraumatic intracerebral haemorrhage (ICH) is a common subtype of stroke with a poor prognosis, high mortality and long-term morbidity. The incidence of ICH increases with age. ICH has not been widely investigated in young adults (herein defined as aged ∼18-50 years) despite an annual incidence of ∼5 per 100,000 individuals. Furthermore, ICH characteristics differ between young and elderly patients. Risk factors for ICH are surprisingly common in young adults, in whom ICH is often caused by structural lesions or hypertension, and only rarely by anticoagulation therapy and cerebral amyloid angiopathy (which are common predisposing factors in elderly patients). High short-term mortality (17% at 3 months) and long-term mortality (>25% at 10 years) persist even in contemporary series from high-income countries, and long-term disability is very common. Thus, an aggressive approach to identifying treatable underlying conditions and preventing ICH recurrence is indicated in young patients, although treatment strategies have generally not been investigated specifically in this age group. This narrative Review summarizes existing knowledge on the epidemiology, risk factors, causes, diagnosis, treatment and outcomes of ICH in young adults. We provide comparisons with the population of elderly patients with ICH and discuss challenges for future research.

Indexed as

Cerebral HemorrhageStrokeAdolescentAdultHumansMiddle AgedYoung Adult

Identifiers

PMID29521335
OpenAlexW2792176663

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.